ID   Y1318_LISMO             Reviewed;         420 AA.
AC   Q8Y7G3;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Putative zinc metalloprotease Lmo1318;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=lmo1318;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR   EMBL; AL591978; CAC99396.1; -; Genomic_DNA.
DR   PIR; AF1239; AF1239.
DR   RefSeq; NP_464843.1; NC_003210.1.
DR   RefSeq; WP_003723454.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q8Y7G3; -.
DR   SMR; Q8Y7G3; -.
DR   STRING; 169963.lmo1318; -.
DR   MEROPS; M50.A11; -.
DR   PaxDb; Q8Y7G3; -.
DR   DNASU; 987698; -.
DR   EnsemblBacteria; CAC99396; CAC99396; CAC99396.
DR   GeneID; 987698; -.
DR   KEGG; lmo:lmo1318; -.
DR   PATRIC; fig|169963.11.peg.1355; -.
DR   eggNOG; COG0750; Bacteria.
DR   HOGENOM; CLU_025778_1_0_9; -.
DR   OMA; QYMVGFG; -.
DR   PhylomeDB; Q8Y7G3; -.
DR   BioCyc; LMON169963:LMO1318-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR42837; PTHR42837; 1.
DR   Pfam; PF13180; PDZ_2; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   TIGRFAMs; TIGR00054; TIGR00054; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Metal-binding; Metalloprotease;
KW   Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc.
FT   CHAIN           1..420
FT                   /note="Putative zinc metalloprotease Lmo1318"
FT                   /id="PRO_0000088447"
FT   TRANSMEM        172..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          176..267
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   ACT_SITE        19
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         18
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         22
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   420 AA;  46717 MW;  220DD2B8B7C63DCF CRC64;
     MTTIIAFIFV FGLIVFFHEL GHFLFAKRAG IMVKDFSIGF GPKIFAYRKK ETQYTIRLLP
     IGGYVRMAGE DGEEIELKPG YRVGLELTPE ETVSKIIVNG KDQYVNAQPI EVSLCDLEKE
     LFIEGYEDYD DTKKVRYQVE RDALVIDGKI ETMITPYDRS FNAKSLGNRA MTIFAGPLFN
     FILAILIFTA LAFVQGGVPS TDNTLGNVLP DGAAAEAGLK KGDEVLSING KETKSWTDIV
     QNVSENPGKT LDFKIERDGK TQDIDVKPAT QKENGKDVGK IGVETPMDSS FTAKITNGFT
     QTWNWIVQIF TILGNMFTGG FSLDMLNGPV GIYTSTQQVV QYGFMTVLNW TAVLSINLGI
     VNLLPLPALD GGRLMFFLYE LVRGKPIDPK KEGIIHFAGF ALLMVLMILV TWNDIQRAFF