Y1318_MYCTU
ID Y1318_MYCTU Reviewed; 541 AA.
AC P9WQ33; L0T7X3; P63527; Q10631;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Uncharacterized protein Rv1318c;
GN OrderedLocusNames=Rv1318c; ORFNames=MTCY130.03c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP44075.1; -; Genomic_DNA.
DR PIR; B70769; B70769.
DR RefSeq; NP_215834.1; NC_000962.3.
DR RefSeq; WP_003406864.1; NZ_NVQJ01000059.1.
DR AlphaFoldDB; P9WQ33; -.
DR SMR; P9WQ33; -.
DR STRING; 83332.Rv1318c; -.
DR PaxDb; P9WQ33; -.
DR DNASU; 886910; -.
DR GeneID; 886910; -.
DR KEGG; mtu:Rv1318c; -.
DR TubercuList; Rv1318c; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG3850; Bacteria.
DR OMA; TMFIPRF; -.
DR PhylomeDB; P9WQ33; -.
DR BRENDA; 4.6.1.1; 3445.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; IDA:MTBBASE.
DR GO; GO:0006171; P:cAMP biosynthetic process; IDA:MTBBASE.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; -; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF55073; SSF55073; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..541
FT /note="Uncharacterized protein Rv1318c"
FT /id="PRO_0000195752"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 278..329
FT /note="HAMP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 361..485
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
SQ SEQUENCE 541 AA; 59332 MW; 24949CC8214386B1 CRC64;
MSAKKSTAQR LGRVLETVTR QSGRLPETPA YGSWLLGRVS ESQRRRRVRI QVMLTALVVT
ANLLGIGVAL LLVTIAIPEP SIVRDTPRWL TFGVVPGYVL LALALGSYAL TRQTVQALRW
AIEGRKPTRE EERRTFLAPW RVAVGHLMFW GVGTALLTTL YGLINNAFIP RFLFAVSFCG
VLVATATYLH TEFALRPFAA QALEAGPPPR RLAPGILGRT MVVWLLGSGV PVVGIALMAM
FEMVLLNLTR MQFATGVLII SMVTLVFGFI LMWILAWLTA TPVRVVRAAL RRVERGELRT
NLVVFDGTEL GELQRGFNAM VAGLRERERV RDLFGRHVGR EVAAAAERER SKLGGEERHV
AVVFIDIVGS TQLVTSRPPA DVVKLLNKFF AIVVDEVDRH HGLVNKFEGD ASLTIFGAPN
RLPCPEDKAL AAARAIADRL VNEMPECQAG IGVAAGQVIA GNVGARERFE YTVIGEPVNE
AARLCELAKS RPGKLLASAQ AVDAASEEER ARWSLGRHVK LRGHDQPVRL AKPVGLTKPR
R