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Y1318_MYCTU
ID   Y1318_MYCTU             Reviewed;         541 AA.
AC   P9WQ33; L0T7X3; P63527; Q10631;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized protein Rv1318c;
GN   OrderedLocusNames=Rv1318c; ORFNames=MTCY130.03c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44075.1; -; Genomic_DNA.
DR   PIR; B70769; B70769.
DR   RefSeq; NP_215834.1; NC_000962.3.
DR   RefSeq; WP_003406864.1; NZ_NVQJ01000059.1.
DR   AlphaFoldDB; P9WQ33; -.
DR   SMR; P9WQ33; -.
DR   STRING; 83332.Rv1318c; -.
DR   PaxDb; P9WQ33; -.
DR   DNASU; 886910; -.
DR   GeneID; 886910; -.
DR   KEGG; mtu:Rv1318c; -.
DR   TubercuList; Rv1318c; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG3850; Bacteria.
DR   OMA; TMFIPRF; -.
DR   PhylomeDB; P9WQ33; -.
DR   BRENDA; 4.6.1.1; 3445.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IDA:MTBBASE.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IDA:MTBBASE.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..541
FT                   /note="Uncharacterized protein Rv1318c"
FT                   /id="PRO_0000195752"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          278..329
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          361..485
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
SQ   SEQUENCE   541 AA;  59332 MW;  24949CC8214386B1 CRC64;
     MSAKKSTAQR LGRVLETVTR QSGRLPETPA YGSWLLGRVS ESQRRRRVRI QVMLTALVVT
     ANLLGIGVAL LLVTIAIPEP SIVRDTPRWL TFGVVPGYVL LALALGSYAL TRQTVQALRW
     AIEGRKPTRE EERRTFLAPW RVAVGHLMFW GVGTALLTTL YGLINNAFIP RFLFAVSFCG
     VLVATATYLH TEFALRPFAA QALEAGPPPR RLAPGILGRT MVVWLLGSGV PVVGIALMAM
     FEMVLLNLTR MQFATGVLII SMVTLVFGFI LMWILAWLTA TPVRVVRAAL RRVERGELRT
     NLVVFDGTEL GELQRGFNAM VAGLRERERV RDLFGRHVGR EVAAAAERER SKLGGEERHV
     AVVFIDIVGS TQLVTSRPPA DVVKLLNKFF AIVVDEVDRH HGLVNKFEGD ASLTIFGAPN
     RLPCPEDKAL AAARAIADRL VNEMPECQAG IGVAAGQVIA GNVGARERFE YTVIGEPVNE
     AARLCELAKS RPGKLLASAQ AVDAASEEER ARWSLGRHVK LRGHDQPVRL AKPVGLTKPR
     R
 
 
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