ID   Y1319_METJA             Reviewed;         492 AA.
AC   Q58715;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Uncharacterized sodium-dependent transporter MJ1319;
GN   OrderedLocusNames=MJ1319;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Putative sodium-dependent transporter.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L77117; AAB99329.1; -; Genomic_DNA.
DR   PIR; F64464; F64464.
DR   AlphaFoldDB; Q58715; -.
DR   SMR; Q58715; -.
DR   STRING; 243232.MJ_1319; -.
DR   TCDB; 2.A.22.5.1; the neurotransmitter:sodium symporter (nss) family.
DR   EnsemblBacteria; AAB99329; AAB99329; MJ_1319.
DR   KEGG; mja:MJ_1319; -.
DR   eggNOG; arCOG04466; Archaea.
DR   HOGENOM; CLU_006855_3_3_2; -.
DR   InParanoid; Q58715; -.
DR   OMA; NLWGFAY; -.
DR   PhylomeDB; Q58715; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616; PTHR11616; 1.
DR   Pfam; PF00209; SNF; 2.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   SUPFAM; SSF161070; SSF161070; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..492
FT                   /note="Uncharacterized sodium-dependent transporter MJ1319"
FT                   /id="PRO_0000214820"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   492 AA;  53468 MW;  A4CEF33AC40D4DB9 CRC64;
     MSYMERESWS SNLGFILASV GSAIGLGNIW RFGYMVYTNG GGAFLIPYIV ALLCVGIPLM
     ILEFAIGHYT KKSAPLALEK LHKGSEWTGW FAVISGFIIT SYYVVIIAWC LYYLIILVIY
     GYPSDPNAYF FHNILQISSG VEDIGGVSYG ILVSTLAVWG IVALILSAGI KNGLEKANKI
     MIPFLLFLII LLVLNALTLP GALTGIEWYL TPDFSALFNY NVWLSAFSQI FFSLSLGFGI
     LIAYASYLPK KSDLTINAVT VSLLNCGFSF LAGFAVFGTL GYMSYTSGIP LDKAVSEGIG
     LAFVTFPKAL SLLPFASRLF GIVFFLALVF AGISSAVSIV EASVSAIIDK FSLSRKKALL
     AVLALFIIIS PIFTTGAGLY YLDIIDHFAS GYLLPIAAIL EIIIAIWLFG GDKLREHVNK
     LSEIKLGVWW KYLAGVVSPI ILTAVVFLDA SNVLTSGYGG YKTTYVIFGA LIIPLAFVVS
     VILQKMKTIK GW