ID   Y1319_MYCTO             Reviewed;         558 AA.
AC   P9WQ30; L0T6A5; P0A4Y2; Q10632;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Uncharacterized protein MT1361;
GN   OrderedLocusNames=MT1361;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45623.1; -; Genomic_DNA.
DR   PIR; C70769; C70769.
DR   RefSeq; WP_003910324.1; NC_002755.2.
DR   AlphaFoldDB; P9WQ30; -.
DR   SMR; P9WQ30; -.
DR   EnsemblBacteria; AAK45623; AAK45623; MT1361.
DR   GeneID; 45425296; -.
DR   KEGG; mtc:MT1361; -.
DR   HOGENOM; CLU_025433_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..558
FT                   /note="Uncharacterized protein MT1361"
FT                   /id="PRO_0000426847"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          279..330
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          362..486
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
FT   REGION          529..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..558
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   558 AA;  60721 MW;  196F00626839B8EE CRC64;
     MPAKKTMAQR LGQALETMTR QCGQLPETPA YGSWLLGRVS ESPSRRWVRI KRIVTVYIMT
     ANLTGIVVAL LVVTFAFPVP SIYTDAPWWV TFGVAPAYAT LALAIGTYWI TTRIVRASIR
     WAIEERAPSQ ADGRNTLLLP FRVAAVHLIL WDIGGALLAT LYGLANRVFV TIILFSVTIC
     GVLVATNCYL FTEFALRPVA AKALEAGRPP RRFAPGIMGR TMTVWSLGSG VPVTGIATTA
     LYVLLVHNLT ETQLASAVLI LSITTLIFGF LVMWILAWLT AAPVRVVRAA LKRVEQGDLR
     GDLVVFDGTE LGELQRGFNA MVNGLRERER VRDLFGRHVG REVAAAAERE RPQLGGEDRH
     AAVVFVDIVG STQLVDNQPA AHVVKLLNRF FAIVVNEVDR HHGLINKFAG DAALAIFGAP
     NRLDRPEDAA LAAARAIADR LANEMPEVQA GIGVAAGQIV AGNVGAKQRF EYTVVGKPVN
     QAARLCELAK SHPARLLASS DTLHAASETE RAHWSLGETV TLRGYHQPTQ LASPHRRPPG
     SIHLTAEHAE EIRTDRLG