ID   Y1320_MYCTU             Reviewed;         567 AA.
AC   P9WQ29; L0T6I3; Q10633;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Uncharacterized protein Rv1320c;
GN   OrderedLocusNames=Rv1320c; ORFNames=MTCY130.05c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44077.1; -; Genomic_DNA.
DR   PIR; D70769; D70769.
DR   RefSeq; NP_215836.1; NC_000962.3.
DR   RefSeq; WP_009935613.1; NZ_NVQJ01000059.1.
DR   AlphaFoldDB; P9WQ29; -.
DR   SMR; P9WQ29; -.
DR   STRING; 83332.Rv1320c; -.
DR   PaxDb; P9WQ29; -.
DR   DNASU; 886906; -.
DR   GeneID; 886906; -.
DR   KEGG; mtu:Rv1320c; -.
DR   TubercuList; Rv1320c; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2972; Bacteria.
DR   OMA; NIGAHER; -.
DR   PhylomeDB; P9WQ29; -.
DR   BRENDA; 4.6.1.1; 3445.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0004016; F:adenylate cyclase activity; IDA:MTBBASE.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..567
FT                   /note="Uncharacterized protein Rv1320c"
FT                   /id="PRO_0000195756"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          278..329
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          361..485
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  61965 MW;  0D6D7C2911FF1839 CRC64;
     MPSEKATTRH LPGAVETLSP RTGRRPETPA YGSWLLGRVS ESPRMRRVRI QGMLTVAILV
     TNVIGLIVGA MLLTVAFPKP SVILDAPHWV SFGIVPGYCV LAFILGTYWL TRQTARALRW
     AIEERTPSHD EARSAFLVPL RVALAVLFLW GAAAALWTII YGLANRLFIP RFLFSMGVIG
     VVAATSCYLL TEFALRPMAA QALEVGATPR SLVRGIVGRT MLVWLLCSGV PNVGVALTAI
     FDDTFWELSN DQFMITVLIL WAPLLIFGFI LMWILAWLTA TPVRVVREAL NRVEQGDLSG
     DLVVFDGTEL GELQRGFNRM VEGLRERERV RDLFGRHVGR EVAAAAERER PKLGGEERHV
     AVVFVDIVGS TQLVTSRPAA EVVMLLNRFF TVIVDEVNHH RGLVNKFQGD ASLAVFGAPN
     RLSHPEDAAL ATARAIADRL ASEMPECQAG IGVAAGQVVA GNVGAHERFE YTVIGEPVNE
     AARLCELAKS YPSRLLASSQ TLRGASENEC ARWSLGETVT LRGHDQPIRL TSPVQQLQMP
     AQSADIVGGA LGDHQTHTIY RGAHPTD