ID   Y1334_METJA             Reviewed;         283 AA.
AC   Q58730;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Putative UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   OrderedLocusNames=MJ1334;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99341.1; -; Genomic_DNA.
DR   PIR; E64466; E64466.
DR   RefSeq; WP_010870852.1; NC_000909.1.
DR   AlphaFoldDB; Q58730; -.
DR   SMR; Q58730; -.
DR   STRING; 243232.MJ_1334; -.
DR   EnsemblBacteria; AAB99341; AAB99341; MJ_1334.
DR   GeneID; 1452237; -.
DR   KEGG; mja:MJ_1334; -.
DR   eggNOG; arCOG00665; Archaea.
DR   HOGENOM; CLU_029499_1_2_2; -.
DR   InParanoid; Q58730; -.
DR   OMA; MHYVRQG; -.
DR   OrthoDB; 78828at2157; -.
DR   PhylomeDB; Q58730; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..283
FT                   /note="Putative UTP--glucose-1-phosphate
FT                   uridylyltransferase"
FT                   /id="PRO_0000201377"
SQ   SEQUENCE   283 AA;  32090 MW;  A98C684C9940F127 CRC64;
     MIRKAVIPVA GFGTRLLPIT KAQPKEMLPV VNKPIVQYVV EDLVEAGVKD ILFVTGKGKQ
     AIENHFDVNY ELECKLEKSG KYELLKIIKE IDRLGNIFYV RQKEQKGLGD AILYGEEFVG
     EEYFIAMVGD TIYSKNIVKD LIKAHEKYGC SVIALERVPK EDVYKYGVID GEEIEKGVYK
     IKNMVEKPKV EEAPSNLIIT GAYLLSPKIF EKIRETPPGR GGEIQITDAM NLLLKEEDII
     GVEINCKRYD IGDALGWLKA NVEIGAERFP EFREFLKEFV KNL