ID   Y1337_MYCTO             Reviewed;         240 AA.
AC   P9WM20; E2IBS6; F2GFD9; P64815; Q10647;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized protein MT1378;
GN   OrderedLocusNames=MT1378;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To M.leprae ML1171. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK45643.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK45643.1; ALT_INIT; Genomic_DNA.
DR   PIR; E70771; E70771.
DR   RefSeq; WP_003898831.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WM20; -.
DR   MEROPS; S54.029; -.
DR   EnsemblBacteria; AAK45643; AAK45643; MT1378.
DR   GeneID; 45425315; -.
DR   KEGG; mtc:MT1378; -.
DR   PATRIC; fig|83331.31.peg.1486; -.
DR   HOGENOM; CLU_067823_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   Gene3D; 1.20.1540.10; -; 1.
DR   InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   Pfam; PF01694; Rhomboid; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..240
FT                   /note="Uncharacterized protein MT1378"
FT                   /id="PRO_0000427380"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   240 AA;  25703 MW;  E43B682C8606CB69 CRC64;
     MGMTPRRKRR GGAVQITRPT GRPRTPTTQT TKRPRWVVGG TTILTFVALL YLVELIDQLS
     GSRLDVNGIR PLKTDGLWGV IFAPLLHANW HHLMANTIPL LVLGFLMTLA GLSRFVWATA
     IIWILGGLGT WLIGNVGSSC GPTDHIGASG LIFGWLAFLL VFGLFVRKGW DIVIGLVVLF
     VYGGILLGAM PVLGQCGGVS WQGHLSGAVA GVVAAYLLSA PERKARALKR AGARSGHPKL