Y1339_DROME
ID Y1339_DROME Reviewed; 430 AA.
AC Q9V4Q0;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Uncharacterized protein CG1339;
GN ORFNames=CG1339;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP DOUBTS ABOUT THE ORIGINAL FUNCTION.
RX PubMed=14608037; DOI=10.1073/pnas.2335847100;
RA Robertson H.M., Warr C.G., Carlson J.R.;
RT "Molecular evolution of the insect chemoreceptor gene superfamily in
RT Drosophila melanogaster.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:14537-14542(2003).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be a putative gustatory receptor
CC named Gr43b but further analysis suggested that this is not the case.
CC {ECO:0000305|PubMed:14608037}.
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DR EMBL; AE013599; AAF59215.4; -; Genomic_DNA.
DR RefSeq; NP_610307.2; NM_136463.2.
DR AlphaFoldDB; Q9V4Q0; -.
DR BioGRID; 61579; 1.
DR DIP; DIP-21241N; -.
DR IntAct; Q9V4Q0; 2.
DR GlyGen; Q9V4Q0; 1 site.
DR PaxDb; Q9V4Q0; -.
DR EnsemblMetazoa; FBtr0347154; FBpp0312485; FBgn0033202.
DR GeneID; 35705; -.
DR KEGG; dme:Dmel_CG1339; -.
DR UCSC; CG1339-RA; d. melanogaster.
DR FlyBase; FBgn0033202; CG1339.
DR VEuPathDB; VectorBase:FBgn0033202; -.
DR eggNOG; ENOG502RTNY; Eukaryota.
DR GeneTree; ENSGT00540000073694; -.
DR HOGENOM; CLU_656006_0_0_1; -.
DR InParanoid; Q9V4Q0; -.
DR OrthoDB; 796247at2759; -.
DR PhylomeDB; Q9V4Q0; -.
DR BioGRID-ORCS; 35705; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35705; -.
DR PRO; PR:Q9V4Q0; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033202; Expressed in organismal segment and 2 other tissues.
DR Genevisible; Q9V4Q0; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 4: Predicted;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..430
FT /note="Uncharacterized protein CG1339"
FT /id="PRO_0000216515"
FT TOPO_DOM 1..31
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..79
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 80..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..110
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 111..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..168
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 169..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 278..298
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..306
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 307..327
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 397..417
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..430
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT CARBOHYD 422
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 430 AA; 50620 MW; 100D976FC0F3323C CRC64;
MSTGSHSPEA MWSATNFRRH QRKPNQVLHR WFFKGSAWII YAIACGLHFF KLHYNERTNQ
VEESQYHRIW SKIVVVLKVI LLASPYLQYF VLGLGIYIHI TLVQDSKAQN FLMSLIVLGI
VIGVLRRLLI FLHLKRDRRF LKHTVNEILH ITSALEQKFG MEYKCDSTLL VVYLAKLWIL
TVMLDSLWYK PYFLSSIFLY WVLLEYCFAG YFIYQLILLS WYHTIILFLQ RFIEDHANRL
DIELHYHRRL IPLFELHLRI NNLHKHVRDN VSWLSTSVYL MIFTCIFNAE LLIECSLFAG
DELENKIYII TDGCLGPVCV PILYVLILGM CTDRFRDAEV QLQQLFVIVQ GLYMRKVRPH
LLIAMVLENE HTSLIIHQKL KPLENMIILD ITCDREFVMD YIVTVILTAL SLVQYTISTG
GNISECVTHK
