ID   Y133_MYCGE              Reviewed;         264 AA.
AC   P47379; Q49489;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2017, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Uncharacterized protein MG133;
GN   OrderedLocusNames=MG133;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-244.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=1945886; DOI=10.1093/nar/19.21.6027;
RA   Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A random sequencing approach for placing markers on the physical map of
RT   Mycoplasma genitalium.";
RL   Nucleic Acids Res. 19:6027-6031(1991).
RN   [3]
RP   SEQUENCE REVISION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=16407165; DOI=10.1073/pnas.0510013103;
RA   Glass J.I., Assad-Garcia N., Alperovich N., Yooseph S., Lewis M.R.,
RA   Maruf M., Hutchison C.A. III, Smith H.O., Venter J.C.;
RT   "Essential genes of a minimal bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:425-430(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Probably essential, it was not disrupted in a
CC       global transposon mutagenesis study. {ECO:0000269|PubMed:16407165}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L43967; AAC71350.2; -; Genomic_DNA.
DR   EMBL; X61537; CAA43749.1; -; Genomic_DNA.
DR   RefSeq; WP_009885689.1; NZ_AAGX01000002.1.
DR   AlphaFoldDB; P47379; -.
DR   STRING; 243273.MG_133; -.
DR   EnsemblBacteria; AAC71350; AAC71350; MG_133.
DR   KEGG; mge:MG_133; -.
DR   eggNOG; ENOG5032G6H; Bacteria.
DR   HOGENOM; CLU_1053017_0_0_14; -.
DR   OrthoDB; 1912545at2; -.
DR   BioCyc; MGEN243273:G1GJ2-147-MON; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011631; DUF1600.
DR   Pfam; PF07667; DUF1600; 1.
DR   PIRSF; PIRSF006834; UCP006834; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..264
FT                   /note="Uncharacterized protein MG133"
FT                   /id="PRO_0000210434"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        237..243
FT                   /note="IPIFASM -> SLFLHQC (in Ref. 2; CAA43749)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   264 AA;  31419 MW;  08035430E82060DC CRC64;
     MLKKSIGIFY RCFYLNNKCD YYLIFLAPFS LFTQIFMVIT ALISVANSGQ MSLIWFTNFD
     TFTYQSNSLA IFLVWYYFLN HKSRWFENSS LVLSVTGYLV FTVIFFNFYA LSRFTGIVNI
     EPDVQGWFST ITTQLPYSFN GSFINDWNAF SELLLHVIHP LFYFIYVGLL FKTYKFIKPP
     RNLQSFLLKA GIYPSIYAFY LQTIPFLNVW DNGENSYSVY GFFTQTKYNS YVWIWSIPIF
     ASMFLILWML FVINNHYYGK KHHK