ID   Y133_MYCPN              Reviewed;         301 AA.
AC   P75265;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Uncharacterized lipoprotein MG186 homolog;
DE   Flags: Precursor;
GN   OrderedLocusNames=MPN_133; ORFNames=E07_orf301, MP021;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=11271496;
RX   DOI=10.1002/1522-2683(200011)21:17<3765::aid-elps3765>3.0.co;2-6;
RA   Regula J.T., Ueberle B., Boguth G., Goerg A., Schnoelzer M., Herrmann R.,
RA   Frank R.;
RT   "Towards a two-dimensional proteome map of Mycoplasma pneumoniae.";
RL   Electrophoresis 21:3765-3780(2000).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U00089; AAB95669.1; -; Genomic_DNA.
DR   PIR; S73347; S73347.
DR   RefSeq; NP_109821.1; NC_000912.1.
DR   RefSeq; WP_010874490.1; NC_000912.1.
DR   AlphaFoldDB; P75265; -.
DR   IntAct; P75265; 1.
DR   STRING; 272634.MPN_133; -.
DR   EnsemblBacteria; AAB95669; AAB95669; MPN_133.
DR   GeneID; 66609217; -.
DR   KEGG; mpn:MPN_133; -.
DR   PATRIC; fig|272634.6.peg.147; -.
DR   HOGENOM; CLU_972608_0_0_14; -.
DR   OMA; NAKINIW; -.
DR   BioCyc; MPNE272634:G1GJ3-225-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.90; -; 1.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR   SMART; SM00318; SNc; 1.
DR   SUPFAM; SSF50199; SSF50199; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS50830; TNASE_3; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Endonuclease; Hydrolase; Lipoprotein; Membrane; Nuclease;
KW   Palmitate; Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           27..301
FT                   /note="Uncharacterized lipoprotein MG186 homolog"
FT                   /id="PRO_0000034399"
FT   DOMAIN          46..243
FT                   /note="TNase-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   REGION          64..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           27
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           27
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   301 AA;  33218 MW;  153C8A774CB3AEFB CRC64;
     MKGFSCSRPG YLTGLLLLAV APILTACTRD YTTKNEFQLT TAQQAKLKPA TIEYWRDGDT
     PEINYASEER RKEAEQKSKE NAKKEDKKEE KKTEDSQDSS SASTQVRSSK HGLRIYGIDT
     PEKHVSSKGD STGDEKIEAE KASNYAEKLI PKGSTVWVWS LNTYSYDREV GALFFKSNPK
     QTFFQSFEVA MVEAGHAIPI AGTGLNLIAD PELSADDPLS VIGLQLANAA NKAYNAKINI
     WSHDTDGYRS LTAVYKLRGA DISWTRFLDE ANGYSSASAG TGASLYQLWD QRQAKLAQKG
     S