ID   Y133_TREPA              Reviewed;         409 AA.
AC   O83169;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Uncharacterized lipoprotein TP_0133;
DE   Flags: Precursor;
GN   OrderedLocusNames=TP_0133;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TP013X lipoprotein family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC65124.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000520; AAC65124.1; ALT_INIT; Genomic_DNA.
DR   PIR; B71363; B71363.
DR   AlphaFoldDB; O83169; -.
DR   IntAct; O83169; 3.
DR   STRING; 243276.TPANIC_0133; -.
DR   PRIDE; O83169; -.
DR   EnsemblBacteria; AAC65124; AAC65124; TP_0133.
DR   KEGG; tpa:TP_0133; -.
DR   HOGENOM; CLU_056007_0_0_12; -.
DR   OMA; SAAQKWN; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..409
FT                   /note="Uncharacterized lipoprotein TP_0133"
FT                   /id="PRO_0000018065"
FT   LIPID           30
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           30
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   409 AA;  43096 MW;  C46E28126C36F65E CRC64;
     MARSRCVHRV VHQAACIGVI GLSTSALTTC DFTGIFVAIQ SEVPIKTPSI PGAIYGLVKA
     GSKLYATNGQ LWKKNVAEEG KDWERESCFD SVIGDSRITS LAADNGENGV LVACILGKGA
     YKWSQGSADQ TSGNPSALSG TEKALSVVGT GTSCVYLNHT DDKVGETSSS ESGGMTASGE
     TNEFCLHAGN GFLVTTKKVC VGSDGSPVAK SDGEEPVPPI LAATDDGSGH VYILTKDKVY
     CKKVNQSEGK IQDCPQSAAA APEPTGAHSV AHKVADAHSI AFFKNGSDEF LLIGGRQGYG
     EIKLERGSGS NGNGAQCVHL KEENVHDQTG WHEKGSTPKG SAEQYRSTIG RWAVSGIYVI
     KKSTSGGRGK RSTSTDCERP DLYVAVGDTN DTYTGLWRFD SAAQKWNRE