ID   Y1349_THEMA             Reviewed;         338 AA.
AC   Q9X170;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Putative transport protein TM_1349;
GN   OrderedLocusNames=TM_1349;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC       family. {ECO:0000305}.
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DR   EMBL; AE000512; AAD36420.1; -; Genomic_DNA.
DR   PIR; E72264; E72264.
DR   RefSeq; NP_229150.1; NC_000853.1.
DR   RefSeq; WP_004081545.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9X170; -.
DR   SMR; Q9X170; -.
DR   STRING; 243274.THEMA_07595; -.
DR   EnsemblBacteria; AAD36420; AAD36420; TM_1349.
DR   KEGG; tma:TM1349; -.
DR   eggNOG; COG0628; Bacteria.
DR   InParanoid; Q9X170; -.
DR   OMA; GAYVKRY; -.
DR   OrthoDB; 1403084at2; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002549; AI-2E-like.
DR   PANTHER; PTHR21716; PTHR21716; 1.
DR   Pfam; PF01594; AI-2E_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..338
FT                   /note="Putative transport protein TM_1349"
FT                   /id="PRO_0000148323"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   338 AA;  39387 MW;  9B21A19682078ADD CRC64;
     MKEFRKILED KAFFFTTLYI LISFLVFKIF PDVFAVIVLM VFFTLLLDPV IRFLEKLKFG
     KYFSRVAALL LFFFVMVYSL YMIIPPVFNE FGSFIEFMTK VFESKIWKDY IKSPELMPVF
     DKIMNFLEPK LTDFLNYVFS LVTTNFVSVT TIIVFTLFGL GYTVFYIREI ASFFVLIYPK
     SVRAEAREFF RDVYASMGRY IRVIFINAVI IGLSYWIVFE AFNLKYSAII SLWAFVTNFI
     PIVGVVLEYI PVLLFSLTLG VKGVLLIALF AILIHAVAFV VFIQLMKGLE KLNPVYIILS
     ILFFGKLFGL FGSFVGVPLA LFFKVFWRKF LRPLFEAG