ID   CAPSD_CACV              Reviewed;         250 AA.
AC   Q8QME6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   02-JUN-2021, entry version 74.
DE   RecName: Full=Probable capsid protein;
GN   Name=Cap; ORFNames=ORF2;
OS   Canary circovirus (CaCV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes;
OC   Cirlivirales; Circoviridae; Circovirus.
OX   NCBI_TaxID=142661;
OH   NCBI_TaxID=9134; Serinus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=19184917; DOI=10.1080/03079450120066322;
RA   Todd D., Weston J., Ball N.W., Borghmans B.J., Smyth J.A., Gelmini L.,
RA   Lavazza A.;
RT   "Nucleotide sequence-based identification of a novel circovirus of
RT   canaries.";
RL   Avian Pathol. 30:321-325(2001).
CC   -!- FUNCTION: Self-assembles to form the virion icosahedral capsid with a
CC       T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows
CC       the virus to be very stable in the environment and resistant to some
CC       disinfectants, including detergents. Essential for the initial
CC       attachment to heparan sulfate moieties and chondroitin sulfate B of the
CC       host cell surface proteoglycans. After attachment, the virus is
CC       endocytosed and traffics to the nucleus. The capsid protein binds and
CC       transports the viral genome and Rep across the nuclear envelope (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Assembles in the nucleus, presumably in an
CC       immature form, then migrates to the cytoplasm once assembled as mature
CC       virion. Interacts with Rep; this interaction relocates Rep into the
CC       nucleus (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the circoviridae capsid protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ301633; CAD23544.1; -; Genomic_DNA.
DR   RefSeq; NP_573443.1; NC_003410.1.
DR   GeneID; 935130; -.
DR   KEGG; vg:935130; -.
DR   Proteomes; UP000007621; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:InterPro.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.950; -; 1.
DR   InterPro; IPR003383; Circovirus_capsid.
DR   InterPro; IPR038652; Circovirus_capsid_sf.
DR   Pfam; PF02443; Circo_capsid; 1.
PE   3: Inferred from homology;
KW   Capsid protein; DNA-binding; Host nucleus; Host-virus interaction;
KW   Reference proteome; T=1 icosahedral capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Viral penetration into host nucleus; Virion; Virus endocytosis by host;
KW   Virus entry into host cell.
FT   CHAIN           1..250
FT                   /note="Probable capsid protein"
FT                   /id="PRO_0000319849"
FT   REGION          1..39
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          9..42
FT                   /note="Nuclear localization signals"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   250 AA;  29994 MW;  ABDFE8C52EC97F1E CRC64;
     MWLTFNQVAR RRRPLAPRRR RWRRRYWXRR RRIPANRRGH RTNRVYRFRF VREFGQVLQK
     GTGGSQLSFG TDGINIILDD FLDWGTINWR LPFEDYRIRL AKVEMRPLNE SWEEWKGFGH
     NVPIQDNHLE DFFKKTRLDA DPLANWDGAR KWDLRKGFKR LFKPRPQLSV TDTDAANVTA
     ALWLNNPKSL WIPIMKKSDQ NLPSSGTRVK HYGLAFSWPE PTPNQMDYQV KVTIYCEFRQ
     MNLTHLATPK