ID   Y1352_MYCBO             Reviewed;         541 AA.
AC   P63528; A0A1R3XY11; Q10631; X2BHJ8;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Uncharacterized protein Mb1352c;
GN   OrderedLocusNames=BQ2027_MB1352C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIT99955.1; -; Genomic_DNA.
DR   RefSeq; NP_855006.1; NC_002945.3.
DR   RefSeq; WP_003406864.1; NC_002945.4.
DR   AlphaFoldDB; P63528; -.
DR   SMR; P63528; -.
DR   EnsemblBacteria; SIT99955; SIT99955; BQ2027_MB1352C.
DR   PATRIC; fig|233413.5.peg.1482; -.
DR   OMA; TMFIPRF; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..541
FT                   /note="Uncharacterized protein Mb1352c"
FT                   /id="PRO_0000195751"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          278..329
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          361..485
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
SQ   SEQUENCE   541 AA;  59332 MW;  24949CC8214386B1 CRC64;
     MSAKKSTAQR LGRVLETVTR QSGRLPETPA YGSWLLGRVS ESQRRRRVRI QVMLTALVVT
     ANLLGIGVAL LLVTIAIPEP SIVRDTPRWL TFGVVPGYVL LALALGSYAL TRQTVQALRW
     AIEGRKPTRE EERRTFLAPW RVAVGHLMFW GVGTALLTTL YGLINNAFIP RFLFAVSFCG
     VLVATATYLH TEFALRPFAA QALEAGPPPR RLAPGILGRT MVVWLLGSGV PVVGIALMAM
     FEMVLLNLTR MQFATGVLII SMVTLVFGFI LMWILAWLTA TPVRVVRAAL RRVERGELRT
     NLVVFDGTEL GELQRGFNAM VAGLRERERV RDLFGRHVGR EVAAAAERER SKLGGEERHV
     AVVFIDIVGS TQLVTSRPPA DVVKLLNKFF AIVVDEVDRH HGLVNKFEGD ASLTIFGAPN
     RLPCPEDKAL AAARAIADRL VNEMPECQAG IGVAAGQVIA GNVGARERFE YTVIGEPVNE
     AARLCELAKS RPGKLLASAQ AVDAASEEER ARWSLGRHVK LRGHDQPVRL AKPVGLTKPR
     R