ID   Y1353_MYCBO             Reviewed;         535 AA.
AC   P0A4Y3; A0A1R3XYC7; Q10632; X2BI01;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Uncharacterized protein Mb1353c;
GN   OrderedLocusNames=BQ2027_MB1353C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIT99956.1; -; Genomic_DNA.
DR   RefSeq; NP_855007.1; NC_002945.3.
DR   RefSeq; WP_003406867.1; NC_002945.4.
DR   AlphaFoldDB; P0A4Y3; -.
DR   SMR; P0A4Y3; -.
DR   EnsemblBacteria; SIT99956; SIT99956; BQ2027_MB1353C.
DR   PATRIC; fig|233413.5.peg.1483; -.
DR   OMA; WITRRTI; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..535
FT                   /note="Uncharacterized protein Mb1353c"
FT                   /id="PRO_0000195753"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          279..330
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          362..486
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
SQ   SEQUENCE   535 AA;  58098 MW;  2B538E38B9C1FC13 CRC64;
     MPAKKTMAQR LGQALETMTR QCGQLPETPA YGSWLLGRVS ESPSRRWVRI KRIVTVYIMT
     ANLTGIVVAL LVVTFAFPVP SIYTDAPWWV TFGVAPAYAT LALAIGTYWI TTRIVRASIR
     WAIEERAPSQ ADGRNTLLLP FRVAAVHLIL WDIGGALLAT LYGLANRVFV TIILFSVTIC
     GVLVATNCYL FTEFALRPVA AKALEAGRPP RRFAPGIMGR TMTVWSLGSG VPVTGIATTA
     LYVLLVHNLT ETQLASAVLI LSITTLIFGF LVMWILAWLT AAPVRVVRAA LKRVEQGDLR
     GDLVVFDGTE LGELQRGFNA MVNGLRERER VRDLFGRHVG REVAAAAERE RPQLGGEDRH
     AAVVFVDIVG STQLVDNQPA AHVVKLLNRF FAIVVNEVDR HHGLINKFAG DAALAIFGAP
     NRLDRPEDAA LAAARAIADR LANEMPEVQA GIGVAAGQIV AGNVGAKQRF EYTVVGKPVN
     QAARLCELAK SHPARLLASS DTLHAASETE RAHWSLGETV TLRGHEQPTR LAVPT