ID   Y1354_MYCBO             Reviewed;         567 AA.
AC   P59972; A0A1R3XY05; X2BHL2;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Uncharacterized protein Mb1354c;
GN   OrderedLocusNames=BQ2027_MB1354C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIT99957.1; -; Genomic_DNA.
DR   RefSeq; NP_855008.1; NC_002945.3.
DR   RefSeq; WP_003898821.1; NC_002945.4.
DR   AlphaFoldDB; P59972; -.
DR   SMR; P59972; -.
DR   EnsemblBacteria; SIT99957; SIT99957; BQ2027_MB1354C.
DR   PATRIC; fig|233413.5.peg.1484; -.
DR   OMA; NIGAHER; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..567
FT                   /note="Uncharacterized protein Mb1354c"
FT                   /id="PRO_0000195755"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          277..329
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          361..485
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  61935 MW;  0D6D7C290C49C349 CRC64;
     MPSEKATTRH LPGAVETLSP RTGRRPETPA YGSWLLGRVS ESPRMRRVRI QGMLTVAILV
     TNVIGLIVGA MLLTVAFPKP SVILDAPHWV SFGIVPGYCV LAFILGTYWL TRQTARALRW
     AIEERTPSHD EARSAFLVPL RVALAVLFLW GAAAALWTII YGLANRLFIP RFLFSMGVIG
     VVAATSCYLL TEFALRPMAA QALEVGATPR SLVRGIVGRT MLVWLLCSGV PNVGVALTAI
     FDDTFWELSN DQFMITVLIL WAPLLIFGFI LMWILAWLTA TPVRVVREAL NRVEQGDLSG
     DLVVFDGTEL GELQRGFNRM VEGLRERERV RDLFGRHVGR EVAAAAERER PKLGGEERHV
     AVVFVDIVGS TQLVTSRPAA EVVMLLNRFF TVIVDEVNHH RGLVNKFQGD ASLAVFGAPN
     RLSHPEDAAL ATARAIADRL ASEMPECQAG IGVAAGQVVA GNVGAHERFE YTVIGEPVNE
     AARLCELAKS YPSRLLASSQ TLRGASENEC ARWSLGETVT LRGHDQPIRL ASPVQQLQMP
     AQSADIVGGA LGDHQTHTIY RGAHPTD