ID   Y1355_LISIN             Reviewed;         420 AA.
AC   Q92C36;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Putative zinc metalloprotease Lin1355;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=lin1355;
OS   Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=272626;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-680 / CLIP 11262;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR   EMBL; AL596168; CAC96586.1; -; Genomic_DNA.
DR   PIR; AB1602; AB1602.
DR   RefSeq; WP_010991494.1; NC_003212.1.
DR   AlphaFoldDB; Q92C36; -.
DR   SMR; Q92C36; -.
DR   STRING; 272626.lin1355; -.
DR   MEROPS; M50.A11; -.
DR   EnsemblBacteria; CAC96586; CAC96586; CAC96586.
DR   GeneID; 61170371; -.
DR   KEGG; lin:lin1355; -.
DR   eggNOG; COG0750; Bacteria.
DR   HOGENOM; CLU_025778_1_0_9; -.
DR   OMA; QYMVGFG; -.
DR   OrthoDB; 1395197at2; -.
DR   Proteomes; UP000002513; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR42837; PTHR42837; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   TIGRFAMs; TIGR00054; TIGR00054; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Metal-binding; Metalloprotease;
KW   Protease; Transmembrane; Transmembrane helix; Zinc.
FT   CHAIN           1..420
FT                   /note="Putative zinc metalloprotease Lin1355"
FT                   /id="PRO_0000088446"
FT   TRANSMEM        172..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          176..260
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   ACT_SITE        19
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         18
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         22
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   420 AA;  46735 MW;  E87894A4F5A42500 CRC64;
     MTTIIAFIFV FGLIVFFHEL GHFLFAKRAG IMVKDFSIGF GPKIFAYRKK ETQYTIRLLP
     IGGYVRMAGE DGEEIELKPG YRVGLELTPE ETVSKIIVNG KDQYVNAQPI EVSLCDLEKE
     LFIEGYEDYD DTKKVRYQVE RNALVIDGKI ETMITPYDRS FNAKSLGNRA MTIFAGPLFN
     FILAILIFTA LAFVQGGVPS TDNTLGNIMP DGAAAQAGLE KGDEVLSING KETKSWTDIV
     QSVSENPGKT LDFKIDRDGK TQDIDVKPAT QKENGKEVGK IGVETPMDTS FTAKITNGFT
     QTWNWIVQIF TILGNMFTGG FSLDMLNGPV GIYTSTQQVV QYGFMTVLNW TAVLSINLGI
     VNLLPLPALD GGRLMFFLYE LVRGKPIDPK KEGIIHFAGF ALLMVLMILV TWNDIQRAFF