ID   Y1357_MYCTU             Reviewed;         307 AA.
AC   P9WM07; L0T814; P64829; Q11027;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Uncharacterized protein Rv1357c;
GN   OrderedLocusNames=Rv1357c; ORFNames=MTCY02B10.21c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP44115.1; -; Genomic_DNA.
DR   PIR; D70741; D70741.
DR   RefSeq; NP_215873.1; NC_000962.3.
DR   RefSeq; WP_003406987.1; NZ_NVQJ01000031.1.
DR   AlphaFoldDB; P9WM07; -.
DR   SMR; P9WM07; -.
DR   STRING; 83332.Rv1357c; -.
DR   PaxDb; P9WM07; -.
DR   DNASU; 886815; -.
DR   GeneID; 886815; -.
DR   KEGG; mtu:Rv1357c; -.
DR   TubercuList; Rv1357c; -.
DR   eggNOG; COG2200; Bacteria.
DR   OMA; PELCIRS; -.
DR   PhylomeDB; P9WM07; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071111; F:cyclic-guanylate-specific phosphodiesterase activity; IDA:MTBBASE.
DR   GO; GO:0051701; P:biological process involved in interaction with host; IMP:MTBBASE.
DR   GO; GO:0009214; P:cyclic nucleotide catabolic process; IDA:MTBBASE.
DR   CDD; cd01948; EAL; 1.
DR   Gene3D; 3.20.20.450; -; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   Pfam; PF00563; EAL; 1.
DR   SMART; SM00052; EAL; 1.
DR   SUPFAM; SSF141868; SSF141868; 1.
DR   PROSITE; PS50883; EAL; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Uncharacterized protein Rv1357c"
FT                   /id="PRO_0000103828"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          54..307
FT                   /note="EAL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00074"
SQ   SEQUENCE   307 AA;  33982 MW;  3DC597A6AB3BAC48 CRC64;
     MDRCCQRATA FACALRPTKL IDYEEMFRGA MQARAMVANP DQWADSDRDQ VNTRHYLSTS
     MRVALDRGEF FLVYQPIIRL ADNRIIGAEA LLRWEHPTLG TLLPGRFIDR AENNGLMVPL
     TAFVLEQACR HVRSWRDHST DPQPFVSVNV SASTICDPGF LVLVEGVLGE TGLPAHALQL
     ELAEDARLSR DEKAVTRLQE LSALGVGIAI DDFGIGFSSL AYLPRLPVDV VKLGGKFIEC
     LDGDIQARLA NEQITRAMID LGDKLGITVT AKLVETPSQA ARLRAFGCKA AQGWHFAKAL
     PVDFFRE