CAPSD_CAV82
ID CAPSD_CAV82 Reviewed; 449 AA.
AC P54090;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Capsid protein;
DE AltName: Full=CA1;
DE AltName: Full=Coat protein;
GN Name=VP1;
OS Chicken anemia virus (isolate Japan 82-2) (CAV).
OC Viruses; Anelloviridae; Gyrovirus.
OX NCBI_TaxID=73476;
OH NCBI_TaxID=9031; Gallus gallus (Chicken).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7778281; DOI=10.1006/viro.1995.1280;
RA Kato A., Fujino M., Nakamura T., Ishihama A., Otaki Y.;
RT "Gene organization of chicken anemia virus.";
RL Virology 209:480-488(1995).
CC -!- FUNCTION: Self-assembles to form the virion icosahedral capsid with a
CC T=1 symmetry. This very small capsid (25 nm in diameter) allows the
CC virus to be very stable in the environment and resistant to some
CC disinfectants, including detergents. Essential for the initial
CC attachment to host receptors. After attachment, the virus is
CC endocytosed and traffics to the nucleus. The capsid protein binds and
CC transports the viral genome and Rep across the nuclear envelope (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimer (Potential). Interacts with Rep; this interaction
CC relocates Rep into the nucleus (By similarity). {ECO:0000250,
CC ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Virion {ECO:0000305}.
CC -!- INDUCTION: VP1 and VP2 are detected 12 hours post infection, while VP3
CC only after 24 hours.
CC -!- SIMILARITY: Belongs to the gyrovirus capsid protein family.
CC {ECO:0000305}.
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DR EMBL; D31965; BAA06734.1; -; Genomic_DNA.
DR Proteomes; UP000008443; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR InterPro; IPR007291; Capsid_protein.
DR Pfam; PF04162; Gyro_capsid; 1.
PE 2: Evidence at transcript level;
KW Capsid protein; DNA-binding; Host nucleus; Host-virus interaction;
KW Late protein; T=1 icosahedral capsid protein;
KW Viral attachment to host cell; Viral penetration into host cytoplasm;
KW Viral penetration into host nucleus; Virion; Virus endocytosis by host;
KW Virus entry into host cell.
FT CHAIN 1..449
FT /note="Capsid protein"
FT /id="PRO_0000222998"
FT REGION 1..43
FT /note="DNA-binding"
FT /evidence="ECO:0000250"
FT REGION 6..47
FT /note="Nuclear localization signals"
FT /evidence="ECO:0000255"
SQ SEQUENCE 449 AA; 51690 MW; 3DEDC29C9A6CAFF1 CRC64;
MERRARRPRG RFYAFRRGRW NHLKRLRRRY KFRHRRRQRY RRRAFRKAFH NPRPGTYSVR
LPNPQSTMTI RFQGVIFLTE GLILPKNSTA GGYADHMYGA RVAKISVNLK EFLLASMNLT
YVSKLGGPIA GELIADGSKS EAAENWPNCC VPLDNNVPSA TPSAWWRWAL MMMQPTDSCR
FFNHPKQMTL QDMGRMFGGW HLFRHIETRF QLLATKNEGS FSPVASLLSQ GEYLTRRDDV
KYSSDHQNRW RKGGQPMTGG IAYATGKMRP DEQQYPAMPP DPPIITSTTA QGTQVRCMNS
TQAWWSWDTY MSFATLTALG AQWSFPPGQR SVSRRSFNHH KARGAGDPKG QRWHTLVPLG
TETITDSYMG APASELDTNF FTLYVAQGTN KSQQYKFGTA TYALKEPVMK SDSWAVVRVQ
SVWQLGNRQR PYPWDVNWAN STMYWGTQP