CAPSD_CAVC1
ID CAPSD_CAVC1 Reviewed; 449 AA.
AC Q99153;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 02-JUN-2021, entry version 85.
DE RecName: Full=Capsid protein;
DE AltName: Full=CA1;
DE AltName: Full=Coat protein;
GN Name=VP1;
OS Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV).
OC Viruses; Anelloviridae; Gyrovirus.
OX NCBI_TaxID=73475;
OH NCBI_TaxID=9031; Gallus gallus (Chicken).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1851873; DOI=10.1128/jvi.65.6.3131-3139.1991;
RA Noteborn M.H.M., de Boer G.F., van Roozelaar D.J., Karreman C.,
RA Kranenburg O., Vos J.G., Jeurissen S.H.M., Hoeben R.C., Zantema A.,
RA Koch G., van Ormondt H., van der Eb A.J.;
RT "Characterization of cloned chicken anemia virus DNA that contains all
RT elements for the infectious replication cycle.";
RL J. Virol. 65:3131-3139(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1605740; DOI=10.1007/bf01309811;
RA Meehan B.M., Todd D., Creelan J.L., Earle J.A.P., Hoey E.M., McNulty M.S.;
RT "Characterization of viral DNAs from cells infected with chicken anaemia
RT agent: sequence analysis of the cloned replicative form and transfection
RT capabilities of cloned genome fragments.";
RL Arch. Virol. 124:301-319(1992).
RN [3]
RP EXPRESSION.
RX PubMed=1511899; DOI=10.1016/0378-1119(92)90198-x;
RA Noteborn M.H.M., Kranenburg O., Zantema A., Koch G., de Boer G.F.,
RA van der Eb A.J.;
RT "Transcription of the chicken anemia virus (CAV) genome and synthesis of
RT its 52-kDa protein.";
RL Gene 118:267-271(1992).
RN [4]
RP INDUCTION.
RX PubMed=9049362; DOI=10.1099/0022-1317-76-7-1557;
RA Douglas A.J., Phenix K., Mawhinney K.A., Todd D., Mackie D.P., Curran W.L.;
RT "Identification of a 24 kDa protein expressed by chicken anaemia virus.";
RL J. Gen. Virol. 76:1557-1562(1995).
RN [5]
RP FUNCTION.
RX PubMed=9880024; DOI=10.1099/0022-1317-79-12-3073;
RA Noteborn M.H., Verschueren C.A., Koch G., Van der Eb A.J.;
RT "Simultaneous expression of recombinant baculovirus-encoded chicken anaemia
RT virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-
RT specific neutralizing epitope.";
RL J. Gen. Virol. 79:3073-3077(1998).
CC -!- FUNCTION: Self-assembles to form the virion icosahedral capsid with a
CC T=1 symmetry. This very small capsid (25 nm in diameter) allows the
CC virus to be very stable in the environment and resistant to some
CC disinfectants, including detergents. Essential for the initial
CC attachment to host receptors. After attachment, the virus is
CC endocytosed and traffics to the nucleus. The capsid protein binds and
CC transports the viral genome and Rep across the nuclear envelope (By
CC similarity). {ECO:0000250, ECO:0000269|PubMed:9880024}.
CC -!- SUBUNIT: Homomultimer (Potential). Interacts with Rep; this interaction
CC relocates Rep into the nucleus (By similarity). {ECO:0000250,
CC ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Virion {ECO:0000305}.
CC -!- INDUCTION: VP1 and VP2 are detected 12 hours post infection, while VP3
CC only after 24 hours. {ECO:0000269|PubMed:9049362}.
CC -!- SIMILARITY: Belongs to the gyrovirus capsid protein family.
CC {ECO:0000305}.
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DR EMBL; M55918; AAA91824.1; -; Genomic_DNA.
DR EMBL; M81223; AAA42884.1; -; Genomic_DNA.
DR PIR; C39926; C39926.
DR RefSeq; NP_056775.1; NC_001427.1.
DR GeneID; 1494446; -.
DR KEGG; vg:1494446; -.
DR Proteomes; UP000007528; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR InterPro; IPR007291; Capsid_protein.
DR Pfam; PF04162; Gyro_capsid; 1.
PE 2: Evidence at transcript level;
KW Capsid protein; DNA-binding; Host nucleus; Host-virus interaction;
KW Late protein; Reference proteome; T=1 icosahedral capsid protein;
KW Viral attachment to host cell; Viral penetration into host cytoplasm;
KW Viral penetration into host nucleus; Virion; Virus endocytosis by host;
KW Virus entry into host cell.
FT CHAIN 1..449
FT /note="Capsid protein"
FT /id="PRO_0000223000"
FT REGION 1..43
FT /note="DNA-binding"
FT /evidence="ECO:0000250"
FT REGION 6..47
FT /note="Nuclear localization signals"
FT /evidence="ECO:0000255"
FT CONFLICT 14
FT /note="S -> A (in Ref. 2; AAA42884)"
FT /evidence="ECO:0000305"
FT CONFLICT 29
FT /note="R -> K (in Ref. 2; AAA42884)"
FT /evidence="ECO:0000305"
FT CONFLICT 254
FT /note="G -> E (in Ref. 2; AAA42884)"
FT /evidence="ECO:0000305"
FT CONFLICT 265
FT /note="T -> N (in Ref. 2; AAA42884)"
FT /evidence="ECO:0000305"
FT CONFLICT 321
FT /note="A -> R (in Ref. 2; AAA42884)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 51723 MW; 96F85F600F4CAD98 CRC64;
MARRARRPRG RFYSFRRGRW HHLKRLRRRY KFRHRRRQRY RRRAFRKAFH NPRPGTYSVR
LPNPQSTMTI RFQGVIFLTE GLILPKNSTA GGYADHMYGA RVAKISVNLK EFLLASMNLT
YVSKIGGPIA GELIADGSKS QAADNWPNCW LPLDNNVPSA TPSAWWRWAL MMMQPTDSCR
FFNHPKQMTL QDMGRMFGGW HLFRHIETRF QLLATKNEGS FSPVASLLSQ GEYLTRRDDV
KYSSDHQNRW QKGGQPMTGG IAYATGKMRP DEQQYPAMPP DPPIITATTA QGTQVRCMNS
TQAWWSWDTY MSFATLTALG AQWSFPPGQR SVSRRSFNHH KARGAGDPKG QRWHTLVPLG
TETITDSYMS APASELDTNF FTLYVAQGTN KSQQYKFGTA TYALKEPVMK SDAWAVVRVQ
SVWQLGNRQR PYPWDVNWAN STMYWGTQP
