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CAPSD_CAVCA
ID   CAPSD_CAVCA             Reviewed;         449 AA.
AC   Q9IZU5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   02-JUN-2021, entry version 64.
DE   RecName: Full=Capsid protein;
DE   AltName: Full=CA1;
DE   AltName: Full=Coat protein;
GN   Name=VP1;
OS   Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV).
OC   Viruses; Anelloviridae; Gyrovirus.
OX   NCBI_TaxID=486492;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11022294; DOI=10.1111/j.1751-0813.2000.tb11942.x;
RA   Brown H.K., Browning G.F., Scott P.C., Crabb B.S., Brown K.;
RT   "Full-length infectious clone of a pathogenic Australian isolate of chicken
RT   anaemia virus.";
RL   Aust. Vet. J. 78:637-640(2000).
CC   -!- FUNCTION: Self-assembles to form the virion icosahedral capsid with a
CC       T=1 symmetry. This very small capsid (25 nm in diameter) allows the
CC       virus to be very stable in the environment and resistant to some
CC       disinfectants, including detergents. Essential for the initial
CC       attachment to host receptors. After attachment, the virus is
CC       endocytosed and traffics to the nucleus. The capsid protein binds and
CC       transports the viral genome and Rep across the nuclear envelope (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer (Potential). Interacts with Rep; this interaction
CC       relocates Rep into the nucleus (By similarity). {ECO:0000250,
CC       ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Virion {ECO:0000305}.
CC   -!- INDUCTION: VP1 and VP2 are detected 12 hours post infection, while VP3
CC       only after 24 hours.
CC   -!- SIMILARITY: Belongs to the gyrovirus capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF227982; AAF34789.1; -; Genomic_DNA.
DR   Proteomes; UP000007539; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR007291; Capsid_protein.
DR   Pfam; PF04162; Gyro_capsid; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; DNA-binding; Host nucleus; Host-virus interaction;
KW   Late protein; T=1 icosahedral capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Viral penetration into host nucleus; Virion; Virus endocytosis by host;
KW   Virus entry into host cell.
FT   CHAIN           1..449
FT                   /note="Capsid protein"
FT                   /id="PRO_0000314473"
FT   REGION          1..43
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          6..47
FT                   /note="Nuclear localization signals"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   449 AA;  51938 MW;  BE77D3B272A5BBD9 CRC64;
     MARRARRPRG RFYAFRRGRW HHLKRLRRRY KFRHRRRQRY RRRAFRKAFH NPRPGTYSVR
     LPNPQSTMTI RFQGVIFLTE GLILPKNSTA GGYADHMYGA RVAKISVNLK EFLLASMNLT
     YVSKIGGPIA GELIADGSKS QAAENWPNCW LPLDNNVPSA TPSAWWRWAL MMMQPTDSCR
     FFNHPKQMTL QDMGRMFGGW HLFRHIETRF QLLATKNEGS FSPVASLLSQ GEYLTRRDDV
     KYSSDHQNRW RKGEQPMTGG IAYATGKMRL DEQQYPAMPP DPPIITTTTA QGTQVRCMNS
     TQAWWSWDTY MSFATLTALG AQWSFPPGQR SVSRRSFNHH KARGAGDPKG QRWHTLVPLG
     TETITDSYMR APASELDTNF FTLYVAQGTN KSQQYKFGTA TYALKEPVMK SDSWAVVRVQ
     SVWQLGNRQR PYPWDVNWAN STMYWGSQP
 
 
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