ID   Y1368_MYCBO             Reviewed;         344 AA.
AC   P64812; A0A1R3XY16; Q10644; X2BI21;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Uncharacterized aminopeptidase Mb1368;
DE            EC=3.4.11.- {ECO:0000250|UniProtKB:Q52VH2};
GN   OrderedLocusNames=BQ2027_MB1368;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Aminopeptidase. {ECO:0000250|UniProtKB:Q52VH2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S58 family. {ECO:0000305}.
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DR   EMBL; LT708304; SIT99971.1; -; Genomic_DNA.
DR   RefSeq; NP_855022.1; NC_002945.3.
DR   RefSeq; WP_003406908.1; NC_002945.4.
DR   AlphaFoldDB; P64812; -.
DR   SMR; P64812; -.
DR   EnsemblBacteria; SIT99971; SIT99971; BQ2027_MB1368.
DR   PATRIC; fig|233413.5.peg.1500; -.
DR   OMA; PHFWAAP; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR016117; ArgJ-like_dom_sf.
DR   InterPro; IPR005321; Peptidase_S58_DmpA.
DR   PANTHER; PTHR36512; PTHR36512; 1.
DR   Pfam; PF03576; Peptidase_S58; 1.
DR   SUPFAM; SSF56266; SSF56266; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Cell membrane; Hydrolase; Membrane; Protease;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..344
FT                   /note="Uncharacterized aminopeptidase Mb1368"
FT                   /id="PRO_0000103809"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   344 AA;  33953 MW;  296A055FECF8E650 CRC64;
     MNSITDVGGI RVGHYQRLDP DASLGAGWAC GVTVVLPPPG TVGAVDCRGG APGTRETDLL
     DPANSVRFVD ALLLAGGSAY GLAAADGVMR WLEEHRRGVA MDSGVVPIVP GAVIFDLPVG
     GWNCRPTADF GYSACAAAGV DVAVGTVGVG VGARAGALKG GVGTASATLQ SGVTVGVLAV
     VNAAGNVVDP ATGLPWMADL VGEFALRAPP AEQIAALAQL SSPLGAFNTP FNTTIGVIAC
     DAALSPAACR RIAIAAHDGL ARTIRPAHTP LDGDTVFALA TGAVAVPPEA GVPAALSPET
     QLVTAVGAAA ADCLARAVLA GVLNAQPVAG IPTYRDMFPG AFGS