Y136_VIBCH
ID Y136_VIBCH Reviewed; 205 AA.
AC Q9KVK7;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Uncharacterized membrane protein VC_0136;
GN OrderedLocusNames=VC_0136 {ECO:0000312|EMBL:AAF93313.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=El Tor A1552 / Serotype O1;
RX PubMed=20622061; DOI=10.1128/jb.00209-10;
RA Liu X., Beyhan S., Lim B., Linington R.G., Yildiz F.H.;
RT "Identification and characterization of a phosphodiesterase that inversely
RT regulates motility and biofilm formation in Vibrio cholerae.";
RL J. Bacteriol. 192:4541-4552(2010).
CC -!- FUNCTION: Involved in positive regulation of motility and negative
CC regulation of biofilm formation. {ECO:0000269|PubMed:20622061}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Deletion mutant exhibits decreased motility.
CC Mutation causes a slight decrease in flaA expression but does not
CC affect flagellar morphology. Mutant has enhanced biofilm formation and
CC vps gene expression. {ECO:0000269|PubMed:20622061}.
CC -!- SIMILARITY: Belongs to the Rht family. {ECO:0000305}.
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DR EMBL; AE003852; AAF93313.1; -; Genomic_DNA.
DR PIR; G82358; G82358.
DR RefSeq; NP_229794.1; NC_002505.1.
DR RefSeq; WP_000351233.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KVK7; -.
DR STRING; 243277.VC_0136; -.
DR PRIDE; Q9KVK7; -.
DR DNASU; 2615265; -.
DR EnsemblBacteria; AAF93313; AAF93313; VC_0136.
DR GeneID; 57741368; -.
DR KEGG; vch:VC_0136; -.
DR PATRIC; fig|243277.26.peg.126; -.
DR eggNOG; COG1280; Bacteria.
DR HOGENOM; CLU_079569_2_1_6; -.
DR OMA; HSLACAF; -.
DR BioCyc; VCHO:VC0136-MON; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042970; F:homoserine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR GO; GO:0042968; P:homoserine transport; IBA:GO_Central.
DR InterPro; IPR001123; LeuE-type.
DR PANTHER; PTHR30086; PTHR30086; 1.
DR Pfam; PF01810; LysE; 1.
DR PIRSF; PIRSF006324; LeuE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..205
FT /note="Uncharacterized membrane protein VC_0136"
FT /id="PRO_0000439661"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 205 AA; 22099 MW; AE42CA6FA6EA1223 CRC64;
MDIHVWLAYL LTAVVFSLAP GSGTVNSISN GLSYGTRHSL GAIIGLQIGL ACHIVLVGIG
IGALVAQSAL AFTLIKWIGA AYLVWLGIQK WRDRAPLTAT TTSHELSQAA LLRKAVLINL
TNPKSIVFLV ALFPQFIDPT RDHWPQFLVL GITTVTIDAI VMFGYTALAA QLGRYIRSPN
IMTRMNKLFG SMFMGCGMLL ATAKA