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Y136_VIBCH
ID   Y136_VIBCH              Reviewed;         205 AA.
AC   Q9KVK7;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Uncharacterized membrane protein VC_0136;
GN   OrderedLocusNames=VC_0136 {ECO:0000312|EMBL:AAF93313.1};
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=El Tor A1552 / Serotype O1;
RX   PubMed=20622061; DOI=10.1128/jb.00209-10;
RA   Liu X., Beyhan S., Lim B., Linington R.G., Yildiz F.H.;
RT   "Identification and characterization of a phosphodiesterase that inversely
RT   regulates motility and biofilm formation in Vibrio cholerae.";
RL   J. Bacteriol. 192:4541-4552(2010).
CC   -!- FUNCTION: Involved in positive regulation of motility and negative
CC       regulation of biofilm formation. {ECO:0000269|PubMed:20622061}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant exhibits decreased motility.
CC       Mutation causes a slight decrease in flaA expression but does not
CC       affect flagellar morphology. Mutant has enhanced biofilm formation and
CC       vps gene expression. {ECO:0000269|PubMed:20622061}.
CC   -!- SIMILARITY: Belongs to the Rht family. {ECO:0000305}.
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DR   EMBL; AE003852; AAF93313.1; -; Genomic_DNA.
DR   PIR; G82358; G82358.
DR   RefSeq; NP_229794.1; NC_002505.1.
DR   RefSeq; WP_000351233.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KVK7; -.
DR   STRING; 243277.VC_0136; -.
DR   PRIDE; Q9KVK7; -.
DR   DNASU; 2615265; -.
DR   EnsemblBacteria; AAF93313; AAF93313; VC_0136.
DR   GeneID; 57741368; -.
DR   KEGG; vch:VC_0136; -.
DR   PATRIC; fig|243277.26.peg.126; -.
DR   eggNOG; COG1280; Bacteria.
DR   HOGENOM; CLU_079569_2_1_6; -.
DR   OMA; HSLACAF; -.
DR   BioCyc; VCHO:VC0136-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042970; F:homoserine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR   GO; GO:0042968; P:homoserine transport; IBA:GO_Central.
DR   InterPro; IPR001123; LeuE-type.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   PIRSF; PIRSF006324; LeuE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..205
FT                   /note="Uncharacterized membrane protein VC_0136"
FT                   /id="PRO_0000439661"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  22099 MW;  AE42CA6FA6EA1223 CRC64;
     MDIHVWLAYL LTAVVFSLAP GSGTVNSISN GLSYGTRHSL GAIIGLQIGL ACHIVLVGIG
     IGALVAQSAL AFTLIKWIGA AYLVWLGIQK WRDRAPLTAT TTSHELSQAA LLRKAVLINL
     TNPKSIVFLV ALFPQFIDPT RDHWPQFLVL GITTVTIDAI VMFGYTALAA QLGRYIRSPN
     IMTRMNKLFG SMFMGCGMLL ATAKA
 
 
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