Y1372_DICDI
ID Y1372_DICDI Reviewed; 999 AA.
AC Q55BF8;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=RING finger domain and kelch repeat-containing protein DDB_G0271372;
GN ORFNames=DDB_G0271372;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT model organism.";
RL PLoS Genet. 2:E38-E38(2006).
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DR EMBL; AAFI02000006; EAL71816.1; -; Genomic_DNA.
DR RefSeq; XP_645654.1; XM_640562.1.
DR AlphaFoldDB; Q55BF8; -.
DR SMR; Q55BF8; -.
DR STRING; 44689.DDB0220714; -.
DR PaxDb; Q55BF8; -.
DR EnsemblProtists; EAL71816; EAL71816; DDB_G0271372.
DR GeneID; 8617846; -.
DR KEGG; ddi:DDB_G0271372; -.
DR dictyBase; DDB_G0271372; -.
DR eggNOG; KOG4441; Eukaryota.
DR HOGENOM; CLU_300046_0_0_1; -.
DR InParanoid; Q55BF8; -.
DR OMA; YINIIGG; -.
DR Reactome; R-DDI-4641258; Degradation of DVL.
DR Reactome; R-DDI-5658442; Regulation of RAS by GAPs.
DR Reactome; R-DDI-8951664; Neddylation.
DR Reactome; R-DDI-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q55BF8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF01344; Kelch_1; 2.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00612; Kelch; 3.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF117281; SSF117281; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil; Kelch repeat; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..999
FT /note="RING finger domain and kelch repeat-containing
FT protein DDB_G0271372"
FT /id="PRO_0000376005"
FT REPEAT 655..700
FT /note="Kelch 1"
FT REPEAT 702..745
FT /note="Kelch 2"
FT REPEAT 748..793
FT /note="Kelch 3"
FT REPEAT 796..842
FT /note="Kelch 4"
FT REPEAT 844..892
FT /note="Kelch 5"
FT ZN_FING 7..49
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 258..302
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT REGION 92..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 355..402
FT /evidence="ECO:0000255"
FT COMPBIAS 159..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 263
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 266
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 286
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 294
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 999 AA; 111635 MW; 06285CA89CFA7665 CRC64;
MDRLLNCPNC LKVFNNPRQL ECDHILCTRC IEGVYNPGRT PIIKCPVCDK HSIVITSIDK
SFPLIHCIEE LLTYKYKDCN YDDSLSIPLN NSTGSSNNNN NNNNNNNNNN NNFVINNSNN
KNNGATTTTT TTTTTTNSNS NSTKSKVVVN DSSPNLISAS PKGLGSSQGS LTTINNQKKL
TLSPQRASST TTTSVNKPPL KLKAISSPPI TPNVSTPERC FVINDKNKHV MISSETTIHN
VSGLSSISTP IVSDAAIAEL SKCNDHDQKK FTIFCTDCDQ LLCDECLNNN QQQHENHQLN
KIIQEAEKRI GDIESMIITT SLCPNRLINK KNKIEKIIQD SALVLKDTKL KITTDIDTMI
ENLKERKNAL ISQIDKEYEE QKLELKDQIE TINTTIVDIQ NNTSITQGIV SLYLNQVDSE
MLSTSLLKKY SDLKRMDQLS DKLSNNLEQN IEWKWEPEYH FPQLFTRSNG EKTTVVYRTK
RVSVGVSSSP TGTGSNGTPQ QQQQQSANGN PTIITTPPLP PISANSPSPT SSSSSTLIGN
IIKRSSPPHL PLSSQNYDNF GSTPPRLTTK LSSPNLSISM PTFPQSNSVQ QNGSTSSIMK
QQSHGSKLND NINTNNNNSP SPTSSSTTST NGSNTKIQLK NPVFGKLLTR KDSVITARRN
WIYGFSDHQV EIYDNVTKVW RGGSKIPKKS IEYSSIYDNN CTIYRFGGKE TPNDIYCYNV
DRDIWEHNKV KIPSKRNAHC SVFDGLRYIY LIGGADRDSS KLLERFDIET QQWTKLASMK
FGRSYFNAFY HPTKRCIYVL DGYVNKDKKS SVEMYSLEKN QWSVICEINQ PRYLSGVSFD
GSKYINIIGG VDRSNSRDIK TMERFDTSTH KWEILNNEPK SLLSHTSSSM NLMVVQSPQL
KKNNSFSSIS SHSSLNSSSS NNGISGSGGS GGDNEIPTEK MQFFNTSFFD GEQFIFFYGI
NIDEHGPLLY KFSIKTKKFE KIPIDNTLDL FSTLIFVSK
