ID   CAPSD_CLVK              Reviewed;         258 AA.
AC   P03561;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Capsid protein;
DE   AltName: Full=Coat protein;
DE            Short=CP;
GN   ORFNames=AR1, AV1;
OS   African cassava mosaic virus (isolate West Kenyan 844) (ACMV) (Cassava
OS   latent virus (isolate West Kenyan 844)).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=10818;
OH   NCBI_TaxID=197394; Hewittia sublobata.
OH   NCBI_TaxID=3996; Jatropha multifida (Coralbush).
OH   NCBI_TaxID=194268; Laportea.
OH   NCBI_TaxID=3983; Manihot esculenta (Cassava) (Jatropha manihot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Stanley J., Gay M.R.;
RT   "Nucleotide sequence of cassava latent virus DNA.";
RL   Nature 301:260-262(1983).
RN   [2]
RP   SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNALS, AND NUCLEAR EXPORT
RP   SIGNAL.
RX   PubMed=11485405; DOI=10.1006/viro.2001.1003;
RA   Unseld S., Hoehnle M., Ringel M., Frischmuth T.;
RT   "Subcellular targeting of the coat protein of African cassava mosaic
RT   geminivirus.";
RL   Virology 286:373-383(2001).
CC   -!- FUNCTION: Encapsidates the viral DNA into characteristic twinned
CC       ('geminate') particles. Binds the genomic viral ssDNA and shuttles it
CC       into and out of the cell nucleus. The CP of bipartite geminiviruses is
CC       not required for cell-to-cell or systemic movement.
CC   -!- SUBUNIT: Homomultimer. Binds to single-stranded and double-stranded
CC       viral DNA. Interacts (via nuclear localization signals) with host
CC       importin alpha-1a (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host nucleus
CC       {ECO:0000269|PubMed:11485405}. Note=It is actively transported into the
CC       host cell nucleus. It may be exported out of the nucleus through a
CC       nuclear export signal for cell-to-cell movement and spread (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; J02057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A04164; QQOMC1.
DR   PDB; 6EK5; EM; 4.20 A; 1/2/3/A/B/B1/B2/B3/BA/BB/BC/BD/BE/BF/BG/BH/BI/BJ/BK/BL/BM/BN/BO/BP/BQ/BR/BS/BT/BU/BV=48-252.
DR   PDBsum; 6EK5; -.
DR   SMR; P03561; -.
DR   Proteomes; UP000008452; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR000650; Gem_coat_AR1.
DR   InterPro; IPR000263; GV_A/BR1_coat.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF00844; Gemini_coat; 1.
DR   PRINTS; PR00224; GEMCOATAR1.
DR   PRINTS; PR00223; GEMCOATARBR1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; DNA-binding; Host nucleus;
KW   Host-virus interaction; Metal-binding; T=1 icosahedral capsid protein;
KW   Viral penetration into host nucleus; Virion; Virus entry into host cell;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..258
FT                   /note="Capsid protein"
FT                   /id="PRO_0000222180"
FT   ZN_FING         69..86
FT                   /evidence="ECO:0000255"
FT   MOTIF           3..20
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           41..55
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           102..123
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           202..249
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   258 AA;  30130 MW;  F22A7F54DB56C9DD CRC64;
     MSKRPGDIII STPGSKVRRR LNFDSPYRNR ATAPTVHVTN RKRAWVNRPM YRKPTMYRMY
     RSPDIPRGCE GPCKVQSFEQ RDDVKHLGIC KVISDVTRGP GLTHRVGKRF CIKSIYILGK
     IWLDETIKKQ NHTNNVIFYL LRDRRPYGNA PQDFGQIFNM FDNEPSTATI KNDLRDRFQV
     LRKFHATVVG GPYGMKEQAL VKRFYRLNHH VTYNHQEAGK YENHTENALL LYMACTHASN
     PVYATLKIRI YFYDSIGN