ID   Y1376_STAAR             Reviewed;          61 AA.
AC   Q6GH41;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable tautomerase SAR1376;
DE            EC=5.3.2.-;
GN   OrderedLocusNames=SAR1376;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SIMILARITY: Belongs to the 4-oxalocrotonate tautomerase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG40374.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX571856; CAG40374.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001123276.1; NC_002952.2.
DR   PDB; 2X4K; X-ray; 1.10 A; A/B=1-61.
DR   PDBsum; 2X4K; -.
DR   AlphaFoldDB; Q6GH41; -.
DR   SMR; Q6GH41; -.
DR   KEGG; sar:SAR1376; -.
DR   HOGENOM; CLU_148073_5_1_9; -.
DR   OMA; MPIVQVE; -.
DR   OrthoDB; 2013680at2; -.
DR   BRENDA; 5.3.2.6; 3352.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006725; P:cellular aromatic compound metabolic process; IEA:InterPro.
DR   CDD; cd00491; 4Oxalocrotonate_Tautomerase; 1.
DR   Gene3D; 3.30.429.10; -; 1.
DR   InterPro; IPR004370; 4-oxalocrotonate_tautomerase.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   InterPro; IPR018191; Tautomerase_Pseudo-typ.
DR   Pfam; PF01361; Tautomerase; 1.
DR   SUPFAM; SSF55331; SSF55331; 1.
DR   TIGRFAMs; TIGR00013; taut; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Isomerase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..61
FT                   /note="Probable tautomerase SAR1376"
FT                   /id="PRO_0000209543"
FT   ACT_SITE        2
FT                   /note="Proton acceptor; via imino nitrogen"
FT                   /evidence="ECO:0000250"
FT   STRAND          3..10
FT                   /evidence="ECO:0007829|PDB:2X4K"
FT   HELIX           14..32
FT                   /evidence="ECO:0007829|PDB:2X4K"
FT   HELIX           36..38
FT                   /evidence="ECO:0007829|PDB:2X4K"
FT   STRAND          40..46
FT                   /evidence="ECO:0007829|PDB:2X4K"
FT   HELIX           48..50
FT                   /evidence="ECO:0007829|PDB:2X4K"
SQ   SEQUENCE   61 AA;  6744 MW;  A62DD8FEAE2A59CE CRC64;
     MPIVNVKLLE GRSDEQLKNL VSEVTDAVEK TTGANRQAIH VVIEEMKPNH YGVAGVRKSD
     Q