ID   Y1378_NEIMB             Reviewed;         148 AA.
AC   P0A0Z0; Q51134;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Putative HTH-type transcriptional regulator NMB1378;
GN   OrderedLocusNames=NMB1378;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CCUG 37602 / M1080 / Serogroup B / Serotype 1;
RX   PubMed=8759842; DOI=10.1128/jb.178.16.4807-4813.1996;
RA   Erwin A.L., Gotschlich E.C.;
RT   "Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-
RT   LDH): evidence for a second meningococcal L-LDH with different
RT   regulation.";
RL   J. Bacteriol. 178:4807-4813(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
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DR   EMBL; U58911; AAB09668.1; -; Genomic_DNA.
DR   EMBL; AE002098; AAF62328.1; -; Genomic_DNA.
DR   RefSeq; NP_274394.1; NC_003112.2.
DR   RefSeq; WP_002213178.1; NC_003112.2.
DR   AlphaFoldDB; P0A0Z0; -.
DR   SMR; P0A0Z0; -.
DR   STRING; 122586.NMB1378; -.
DR   PaxDb; P0A0Z0; -.
DR   EnsemblBacteria; AAF62328; AAF62328; NMB1378.
DR   GeneID; 61281566; -.
DR   KEGG; nme:NMB1378; -.
DR   PATRIC; fig|122586.8.peg.1728; -.
DR   HOGENOM; CLU_107144_0_0_4; -.
DR   OMA; YGLTIMM; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR010242; TF_HTH_IscR.
DR   InterPro; IPR030489; TR_Rrf2-type_CS.
DR   InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33221; PTHR33221; 1.
DR   Pfam; PF02082; Rrf2; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR02010; IscR; 1.
DR   TIGRFAMs; TIGR00738; rrf2_super; 1.
DR   PROSITE; PS01332; HTH_RRF2_1; 1.
DR   PROSITE; PS51197; HTH_RRF2_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome.
FT   CHAIN           1..148
FT                   /note="Putative HTH-type transcriptional regulator NMB1378"
FT                   /id="PRO_0000036208"
FT   DOMAIN          2..131
FT                   /note="HTH rrf2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT   CONFLICT        8..9
FT                   /note="RF -> LS (in Ref. 1; AAB09668)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        132..148
FT                   /note="QKNNGDGSRVVQFTHIH -> TEKQRRRQPRSSNLHTSIK (in Ref. 1;
FT                   AAB09668)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   148 AA;  15985 MW;  E7CF370DE5D9BFBA CRC64;
     MRLTTKGRFA VTAMLDLAMN AQTGAVKLSA ISERQNISLS YLEQLFGKLR RAGLVESLRG
     PGGGYILAAP AARINIAQII AAAEDRLDAT QCGSKANCHH GAPCLTHDLW ENLNKTINDY
     LGSVTLQSII EQKNNGDGSR VVQFTHIH