ID   Y1383_STAES             Reviewed;         351 AA.
AC   Q8CNW9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Uncharacterized peptidase SE_1383;
DE            EC=3.4.-.-;
GN   OrderedLocusNames=SE_1383;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000305};
CC       Note=Binds 2 manganese ions per subunit. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO04982.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE015929; AAO04982.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_764938.1; NC_004461.1.
DR   RefSeq; WP_001830888.1; NC_004461.1.
DR   AlphaFoldDB; Q8CNW9; -.
DR   SMR; Q8CNW9; -.
DR   STRING; 176280.SE_1383; -.
DR   EnsemblBacteria; AAO04982; AAO04982; SE_1383.
DR   GeneID; 50018503; -.
DR   KEGG; sep:SE_1383; -.
DR   PATRIC; fig|176280.10.peg.1351; -.
DR   eggNOG; COG0006; Bacteria.
DR   HOGENOM; CLU_017266_4_2_9; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.350.10; -; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   SUPFAM; SSF53092; SSF53092; 1.
DR   SUPFAM; SSF55920; SSF55920; 1.
DR   PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Metal-binding.
FT   CHAIN           1..351
FT                   /note="Uncharacterized peptidase SE_1383"
FT                   /id="PRO_0000299429"
FT   BINDING         215
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         226
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         226
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
FT   BINDING         290
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         319
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         333
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255"
FT   BINDING         333
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   351 AA;  40184 MW;  A1876501DAA8AB01 CRC64;
     MTKIKEIKKV LQQEDADAAW ITTPLNIFYF TGYRSEPHER LFALLIPSNE EPVLFCPKME
     VEEVKQSPFK GKIIGYLDTE NPFDKYSKTF SKMLIESEHL TVKRQRELTK AFNIEHYQDV
     DQSIKDLRNI KSEDEIINIK KAAALADKCI EIGKSFLKEG VEEREVVNHI ENEIKKYGVN
     EMSFDTMVLF GDHAASPHGT PGDRKLQQNE FVLFDLGVVY HHYCSDMTRT IHFGTPNKEA
     QNIYNIVLKA ETEAIKSIKP GVTIKDIDKI ARDIIEEAGY GDYFPHRLGH GLGLEEHEYQ
     DISSVNNNQL EAGMVITIEP GIYVPHVAGV RIEDDILVTE NGYEILTQYE K