Y1385_ARATH
ID Y1385_ARATH Reviewed; 548 AA.
AC Q9CAJ9; Q8GYN4;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=BTB/POZ domain-containing protein At1g63850;
GN OrderedLocusNames=At1g63850; ORFNames=T12P18.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-226.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC42152.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
CC Sequence=BAC42152.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC010852; AAG52452.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34156.1; -; Genomic_DNA.
DR EMBL; AK117489; BAC42152.1; ALT_SEQ; mRNA.
DR PIR; F96663; F96663.
DR RefSeq; NP_176570.1; NM_105060.2.
DR AlphaFoldDB; Q9CAJ9; -.
DR BioGRID; 27909; 2.
DR iPTMnet; Q9CAJ9; -.
DR PaxDb; Q9CAJ9; -.
DR PRIDE; Q9CAJ9; -.
DR ProteomicsDB; 242432; -.
DR EnsemblPlants; AT1G63850.1; AT1G63850.1; AT1G63850.
DR GeneID; 842688; -.
DR Gramene; AT1G63850.1; AT1G63850.1; AT1G63850.
DR KEGG; ath:AT1G63850; -.
DR Araport; AT1G63850; -.
DR TAIR; locus:2195488; AT1G63850.
DR eggNOG; ENOG502QST3; Eukaryota.
DR HOGENOM; CLU_025834_0_0_1; -.
DR InParanoid; Q9CAJ9; -.
DR OMA; FTRFNSM; -.
DR OrthoDB; 512599at2759; -.
DR PhylomeDB; Q9CAJ9; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9CAJ9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9CAJ9; baseline and differential.
DR Genevisible; Q9CAJ9; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR038920; BTB/POZ_dom_prot.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR31060; PTHR31060; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..548
FT /note="BTB/POZ domain-containing protein At1g63850"
FT /id="PRO_0000408527"
FT DOMAIN 141..220
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
SQ SEQUENCE 548 AA; 61495 MW; 71391BE7F7EA3529 CRC64;
MDYSTATTTA GNGYSSPRDS SFPSSFTKFN SALTAGLLNP MSPPPPPAMH DKTRSSPTLF
EMMASEADTI GKVPVQIHNG VLPSPSSSSS SSSAAATAAR TTNVNHLVIS AQDKQALAMQ
RISDLLVIRS PGNQFNDPNS SDVKLTLSSK DGISITMCVH RQILVAHSRF FAMKLSDRWS
KQQLPPSSSP YIVEISDCDD VEVYIETLML MYCRDLRKKM MRHDVSRVLG ILKVSAAIGF
DAGVLSCLEY LEAAPWSEDE EYRIASLLSE LHLENVGATE VLRRVSVEAS NGNNGSNGGS
NDEVLLNLLH IVLEGKDEKA RRDMKTLVSK MLRENSSGND LRKESLYLAC DGCLHKLKRQ
FLQAAESDLE NVDQIARQAD NLHWILDILI DRQIAEDFIV MWASLSELSE VHSKVPVVHR
FEISRVTARI FVGIGKGQIL TPKEVRCLLL RNWLTPFYDD FGWMRRASKG LDRYLIEDGL
SNTILTLPLA WQQEFFLAWF DRFLNSNEDC PNIQRGFEVW WRRAFWRRKE QSQEPARLRV
TASATENS
