ID   Y1388_MYCBO             Reviewed;         261 AA.
AC   P67435; A0A1R3XY41; Q11023; X2BI41;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Mb1388c;
GN   OrderedLocusNames=BQ2027_MB1388C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
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DR   EMBL; LT708304; SIT99991.1; -; Genomic_DNA.
DR   RefSeq; NP_855042.1; NC_002945.3.
DR   RefSeq; WP_003898836.1; NC_002945.4.
DR   AlphaFoldDB; P67435; -.
DR   SMR; P67435; -.
DR   EnsemblBacteria; SIT99991; SIT99991; BQ2027_MB1388C.
DR   GeneID; 45425332; -.
DR   PATRIC; fig|233413.5.peg.1520; -.
DR   OMA; MGNPILC; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR004111; Repressor_TetR_C.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF02909; TetR_C_1; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..261
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Mb1388c"
FT                   /id="PRO_0000070661"
FT   DOMAIN          15..75
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        38..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   REGION          234..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  28253 MW;  12B447D94D8B03AC CRC64;
     MQTTPGKRQR RQRGSINPED IISGAFELAQ QVSIDNLSMP LLGKHLGVGV TSIYWYFRKK
     DDLLNAMTDR ALSKYVFATP YIEAGDWRET LRNHARSMRK TFADNPVLCD LILIRAALSP
     KTARLGAQEM EKAIANLVTA GLSLEDAFDI YSAVSVHVRG SVVLDRLSRK SQSAGSGPSA
     IEHPVAIDPA TTPLLAHATG RGHRIGAPDE TNFEYGLECI LDHAGRLIEQ SSKAAGEVAV
     RRPTATADAP TPGARAKAVA R