ID   Y1395_MYCTO             Reviewed;         344 AA.
AC   P9WMJ0; L0T999; P68913; P71663;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MT1440;
GN   OrderedLocusNames=MT1440;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
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DR   EMBL; AE000516; AAK45705.1; -; Genomic_DNA.
DR   RefSeq; WP_003407264.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMJ0; -.
DR   SMR; P9WMJ0; -.
DR   EnsemblBacteria; AAK45705; AAK45705; MT1440.
DR   KEGG; mtc:MT1440; -.
DR   PATRIC; fig|83331.31.peg.1546; -.
DR   HOGENOM; CLU_047522_3_3_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR032687; AraC-type_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12625; Arabinose_bd; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MT1440"
FT                   /id="PRO_0000427295"
FT   DOMAIN          242..343
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        263..284
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        310..333
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   344 AA;  37894 MW;  131FB83BC8C25EA7 CRC64;
     MGHLPPPAEV RHPVYATRVL CEVANERGVP TADVLAGTAI EPADLDDPDA VVGALDEITA
     VRRLLARLPD DAGIGIDVGS RFALTHFGLF GFAVMSCGTL RELLTIAMRY FALTTMHVDI
     TLFETADDCL VELDASHLPA DVRGFFIERD IAGIIATTTS FALPLAAKYA DQVSAELAVD
     AELLRPLLEL VPVHDVAFGR AHNRVHFPRA MFDEPLPQAD RHTLEMCIAQ CDVLMQRNER
     RRGITALVRS KLFRDSGLFP TFTDVAGELD MHPRTLRRRL AEEGTSFRAL LGEARSTVAV
     DLLRNVGLTV QQVSTRLGYT EVSTFSHAFK RWYGVAPSEY SRRG