ID   Y1395_MYCTU             Reviewed;         344 AA.
AC   P9WMJ1; L0T999; P68913; P71663;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv1395;
GN   OrderedLocusNames=Rv1395; ORFNames=MTCY21B4.12;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12368430; DOI=10.1099/00221287-148-10-2967;
RA   Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
RT   "Re-annotation of the genome sequence of Mycobacterium tuberculosis
RT   H37Rv.";
RL   Microbiology 148:2967-2973(2002).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
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DR   EMBL; AL123456; CCP44154.1; -; Genomic_DNA.
DR   RefSeq; WP_003407264.1; NZ_NVQJ01000050.1.
DR   RefSeq; YP_177808.1; NC_000962.3.
DR   AlphaFoldDB; P9WMJ1; -.
DR   SMR; P9WMJ1; -.
DR   STRING; 83332.Rv1395; -.
DR   PaxDb; P9WMJ1; -.
DR   GeneID; 886251; -.
DR   KEGG; mtu:Rv1395; -.
DR   TubercuList; Rv1395; -.
DR   eggNOG; COG2207; Bacteria.
DR   OMA; RYHFSAY; -.
DR   PhylomeDB; P9WMJ1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IDA:MTBBASE.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:MTBBASE.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0051701; P:biological process involved in interaction with host; IMP:MTBBASE.
DR   InterPro; IPR032687; AraC-type_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12625; Arabinose_bd; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Rv1395"
FT                   /id="PRO_0000194624"
FT   DOMAIN          242..343
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        263..284
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        310..333
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   344 AA;  37894 MW;  131FB83BC8C25EA7 CRC64;
     MGHLPPPAEV RHPVYATRVL CEVANERGVP TADVLAGTAI EPADLDDPDA VVGALDEITA
     VRRLLARLPD DAGIGIDVGS RFALTHFGLF GFAVMSCGTL RELLTIAMRY FALTTMHVDI
     TLFETADDCL VELDASHLPA DVRGFFIERD IAGIIATTTS FALPLAAKYA DQVSAELAVD
     AELLRPLLEL VPVHDVAFGR AHNRVHFPRA MFDEPLPQAD RHTLEMCIAQ CDVLMQRNER
     RRGITALVRS KLFRDSGLFP TFTDVAGELD MHPRTLRRRL AEEGTSFRAL LGEARSTVAV
     DLLRNVGLTV QQVSTRLGYT EVSTFSHAFK RWYGVAPSEY SRRG