ID   Y1398_CORDI             Reviewed;         420 AA.
AC   Q6NGV2;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Uncharacterized RNA methyltransferase DIP1398;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=DIP1398;
OS   Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype
OS   gravis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=257309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
RX   PubMed=14602910; DOI=10.1093/nar/gkg874;
RA   Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G.,
RA   Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D.,
RA   De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N.,
RA   Holroyd S., Jagels K., Moule S., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G.,
RA   Parkhill J.;
RT   "The complete genome sequence and analysis of Corynebacterium diphtheriae
RT   NCTC13129.";
RL   Nucleic Acids Res. 31:6516-6523(2003).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA M5U methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01024}.
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DR   EMBL; BX248358; CAE49929.1; -; Genomic_DNA.
DR   RefSeq; WP_010935042.1; NC_002935.2.
DR   AlphaFoldDB; Q6NGV2; -.
DR   SMR; Q6NGV2; -.
DR   STRING; 257309.DIP1398; -.
DR   DNASU; 2649473; -.
DR   EnsemblBacteria; CAE49929; CAE49929; DIP1398.
DR   KEGG; cdi:DIP1398; -.
DR   PATRIC; fig|257309.4.peg.1378; -.
DR   HOGENOM; CLU_014689_7_0_11; -.
DR   OMA; FYAGDMK; -.
DR   OrthoDB; 1421660at2; -.
DR   Proteomes; UP000002198; Chromosome.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR030390; MeTrfase_TrmA_AS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR010280; U5_MeTrfase_fam.
DR   PANTHER; PTHR11061; PTHR11061; 2.
DR   Pfam; PF01938; TRAM; 1.
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR   PROSITE; PS50926; TRAM; 1.
DR   PROSITE; PS01230; TRMA_1; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..420
FT                   /note="Uncharacterized RNA methyltransferase DIP1398"
FT                   /id="PRO_0000161974"
FT   DOMAIN          7..65
FT                   /note="TRAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00208"
FT   ACT_SITE        376
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         245
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         280
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         304
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         349
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
SQ   SEQUENCE   420 AA;  44995 MW;  77ED73D09E75E097 CRC64;
     MTKDQQNIER GSVINVEILN AAHGGQGIAK YDGRVIFVKG AFPGDRLSAN ITHVKKKFAR
     ATIASIEMPS PLRMQQRCLA AANGAGCCDF GEFDPEIEGR YKADLVLEQL ERLGKVSQPP
     TCEVVSFGSP TQWRTRMRLG VDAQGRAGGF ASQSREVVSG VPCSQGVMGL LDGIVGAEQN
     VLRFTPGSQV VVVCDDLGQR TVVETQPAPR GKRTESMVKV VEGTGKVSQV VDGVTFELPA
     TGFWQSHKDA AQAYADTIRE WFGSLIIRNT DSSLVAWDLY GGCGSFASAI LSAVDNHGVV
     HCVESAPAAV SAGKRALSQL VEDQKIVFHT ETVERAMNQL PAPTLVVLDP PRVGAGAETV
     RAIAQSGPQA AIHIGCDPAT FARDIAEWSR NGFILEKLRV FDAFPGTHHC ETIGLLTKKN