ID   Y1401_SACS2             Reviewed;         323 AA.
AC   Q97YC5;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Putative CRISPR-associated protein SSO1401;
GN   OrderedLocusNames=SSO1401;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN   [2]
RP   SUBUNIT.
RC   STRAIN=ATCC 35091 / DSM 1616 / JCM 8930 / NBRC 15331 / P1;
RX   PubMed=21507944; DOI=10.1074/jbc.m111.238485;
RA   Lintner N.G., Kerou M., Brumfield S.K., Graham S., Liu H., Naismith J.H.,
RA   Sdano M., Peng N., She Q., Copie V., Young M.J., White M.F., Lawrence C.M.;
RT   "Structural and functional characterization of an archaeal clustered
RT   regularly interspaced short palindromic repeat (CRISPR)-associated complex
RT   for antiviral defense (CASCADE).";
RL   J. Biol. Chem. 286:21643-21656(2011).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Sometimes seen associated with the aCascade ribonucleoprotein
CC       complex, minimally composed of Csa2 and Cas5a, which binds crRNA. Other
CC       probable components of aCascade in strain P1 are Cas6 and Csa5, while
CC       SSO1399, Cas5b (SSO1400) and SSO1401 have sometimes been seen weakly
CC       associated. The Csa2-Cas5a-crRNA complex also binds target DNA
CC       homologous to crRNA, probably forming an R-loop. Purified aCascade
CC       forms a filament about 6 nm in width. {ECO:0000269|PubMed:21507944}.
CC   -!- MISCELLANEOUS: The aCascade complex was purified from strain P1.
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DR   EMBL; AE006641; AAK41636.1; -; Genomic_DNA.
DR   PIR; E90297; E90297.
DR   RefSeq; WP_009988397.1; NC_002754.1.
DR   AlphaFoldDB; Q97YC5; -.
DR   STRING; 273057.SSO1401; -.
DR   EnsemblBacteria; AAK41636; AAK41636; SSO1401.
DR   GeneID; 44130257; -.
DR   KEGG; sso:SSO1401; -.
DR   PATRIC; fig|273057.12.peg.1417; -.
DR   eggNOG; arCOG07297; Archaea.
DR   HOGENOM; CLU_859487_0_0_2; -.
DR   OMA; EEMAYFI; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..323
FT                   /note="Putative CRISPR-associated protein SSO1401"
FT                   /id="PRO_0000417887"
SQ   SEQUENCE   323 AA;  37140 MW;  9599D14AC93D618F CRC64;
     MVFKINLPPE GLFARSLVIS ELLGLNNVGI SIDNDVVNIE RKEEFKDNLK NELSQFKLVF
     NKLKTYKKNY ANEVNLAEKV FNGDVEEFFK EDKEEYFLPL IFPEIMEAEK WFGGWSGSGK
     GSKRTIGVNR QSFILSLLSL GKYQLVSYRA AKEQVTVLAL VDTTVMSDMC KPSKKKELRV
     QSNLIAQLSH ISRLLIFSTI LDEQGCQEVL LLKEGTHRAE IYERNSHTSL RPLIRFWTLV
     DDDSVERRIT SLANQSPDSL NKVSNYIFEG IRGTLSPVEV AYMIARETYL KEEQSPLTSW
     DVKKIREALE RMRVEMEEVY SST