ID   Y1407_CLOP1             Reviewed;         662 AA.
AC   Q0TR88;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=UPF0313 protein CPF_1407 {ECO:0000255|HAMAP-Rule:MF_01251};
GN   OrderedLocusNames=CPF_1407;
OS   Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB
OS   6125 / NCTC 8237 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / S 107 /
RC   Type A;
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA   Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA   Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA   Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA   Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA   Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT   Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01251};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000255|HAMAP-Rule:MF_01251};
CC   -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01251}.
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DR   EMBL; CP000246; ABG84851.1; -; Genomic_DNA.
DR   RefSeq; WP_011590696.1; NC_008261.1.
DR   AlphaFoldDB; Q0TR88; -.
DR   SMR; Q0TR88; -.
DR   STRING; 195103.CPF_1407; -.
DR   EnsemblBacteria; ABG84851; ABG84851; CPF_1407.
DR   GeneID; 29571481; -.
DR   KEGG; cpf:CPF_1407; -.
DR   eggNOG; COG1032; Bacteria.
DR   HOGENOM; CLU_018288_2_0_9; -.
DR   OMA; TCMYYTG; -.
DR   OrthoDB; 229299at2; -.
DR   Proteomes; UP000001823; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.30.20; -; 1.
DR   HAMAP; MF_01251; UPF0313; 1.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR022946; UPF0313.
DR   InterPro; IPR024560; UPF0313_C.
DR   InterPro; IPR013704; UPF0313_N.
DR   PANTHER; PTHR32331; PTHR32331; 1.
DR   Pfam; PF11842; DUF3362; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF08497; Radical_SAM_N; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01069; UPF0313; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; S-adenosyl-L-methionine.
FT   CHAIN           1..662
FT                   /note="UPF0313 protein CPF_1407"
FT                   /id="PRO_1000067193"
FT   DOMAIN          296..567
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   REGION          596..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..654
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         310
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         314
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         317
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
SQ   SEQUENCE   662 AA;  76142 MW;  39BA0DFA0FD29038 CRC64;
     MSENKFLPIC KDDMIERGWE QCDFVLVTAD AYIDHHSFGT AIISRVLENA GYKVGIIAQP
     DWKSVDDFKK LGRPRLGFLV NGGNMDPMVN HYTVSKKLRK KDLYTPKGEM GKRPDRATIV
     YCNKIREAYK DVNIVIGGIE ASLRRFAHYD YWDNKVRKSI LVDSGADLLV YGMSEKQIVE
     VADFLNQGFD GKYIRHIPGT CYIADSLDEI YEEHIVLPSF KEVSSDKRTY AECFKIQYDE
     QDPVRGRTLV QEHNGKYVVI NKPEMPLSRE ELDRVYALPY QKTYHPIYEK DGGIAAIEEV
     KFSIVSSRGC SGNCSFCAIT FHQGRIVTSR SEDSIVEEAE EITKYDDFKG YIHDIGGPTA
     NFRKPACKKQ LTLGACKHKR CMSPGICKNM EVDHREYLHL LRRVRKLPGI KKVFIRSGLR
     YDYIMADKDD TFFKELVEHH VSGQLKVAPE HVSPNVLKYM GKPAGKTYDE FRRKFFRITE
     RLGKKQFIIP YLMSSHPGCK LEDAIMLAEY LRDINYQPEQ VQDFYPTPGT LSTTMFYTGL
     DPLTMEEVYI PRSKEEKAMQ RALLQFKNPK NYNIVYDALV KVGREDLIGN GPKCLIRDKN
     SFGKGNNHSN HKSGGRKSRN ENSGRRESED KKRSSHSKKQ RGNKSRGFDQ KSQRSSKGKK
     RR