ID   Y1407_MYCTO             Reviewed;         457 AA.
AC   P9WGX2; L0T6K0; P71675;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Putative methyltransferase MT1451;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MT1451;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: May act as RNA methyltransferase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RsmB/NOP family. {ECO:0000255|PROSITE-ProRule:PRU01023}.
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DR   EMBL; AE000516; AAK45716.1; -; Genomic_DNA.
DR   PIR; D70901; D70901.
DR   RefSeq; WP_003898865.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGX2; -.
DR   SMR; P9WGX2; -.
DR   EnsemblBacteria; AAK45716; AAK45716; MT1451.
DR   KEGG; mtc:MT1451; -.
DR   PATRIC; fig|83331.31.peg.1559; -.
DR   HOGENOM; CLU_005316_0_3_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR   Gene3D; 1.10.940.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR018314; Fmu/NOL1/Nop2p_CS.
DR   InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR   InterPro; IPR035926; NusB-like_sf.
DR   InterPro; IPR006027; NusB_RsmB_TIM44.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22807; PTHR22807; 1.
DR   Pfam; PF01189; Methyltr_RsmB-F; 1.
DR   Pfam; PF01029; NusB; 1.
DR   PRINTS; PR02008; RCMTFAMILY.
DR   SUPFAM; SSF48013; SSF48013; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS01153; NOL1_NOP2_SUN; 1.
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; RNA-binding; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..457
FT                   /note="Putative methyltransferase MT1451"
FT                   /id="PRO_0000428287"
FT   ACT_SITE        394
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01023"
FT   BINDING         276..282
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01023"
FT   BINDING         301
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01023"
FT   BINDING         325
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01023"
FT   BINDING         341
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01023"
SQ   SEQUENCE   457 AA;  48493 MW;  A90DEFCDBABA8C4D CRC64;
     MTPRSRGPRR RPLDPARRAA FETLRAVSAR DAYANLVLPA LLAQRGIGGR DAAFATELTY
     GTCRARGLLD AVIGAAAERS PQAIDPVLLD LLRLGTYQLL RTRVDAHAAV STTVEQAGIE
     FDSARAGFVN GVLRTIAGRD ERSWVGELAP DAQNDPIGHA AFVHAHPRWI AQAFADALGA
     AVGELEAVLA SDDERPAVHL AARPGVLTAG ELARAVRGTV GRYSPFAVYL PRGDPGRLAP
     VRDGQALVQD EGSQLVARAL TLAPVDGDTG RWLDLCAGPG GKTALLAGLG LQCAARVTAV
     EPSPHRADLV AQNTRGLPVE LLRVDGRHTD LDPGFDRVLV DAPCTGLGAL RRRPEARWRR
     QPADVAALAK LQRELLSAAI ALTRPGGVVL YATCSPHLAE TVGAVADALR RHPVHALDTR
     PLFEPVIAGL GEGPHVQLWP HRHGTDAMFA AALRRLT