Y140_MYCGE
ID Y140_MYCGE Reviewed; 1113 AA.
AC P47386; Q49203; Q49283; Q49445; Q49472;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Uncharacterized ATP-dependent helicase MG140;
DE EC=3.6.4.-;
GN OrderedLocusNames=MG140;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 206-267.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=1945886; DOI=10.1093/nar/19.21.6027;
RA Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A random sequencing approach for placing markers on the physical map of
RT Mycoplasma genitalium.";
RL Nucleic Acids Res. 19:6027-6031(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-267; 294-394 AND 999-1100.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. {ECO:0000305}.
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DR EMBL; L43967; AAC71358.1; -; Genomic_DNA.
DR EMBL; X61512; CAA43726.1; -; Genomic_DNA.
DR EMBL; U01729; AAC43207.1; -; Unassigned_DNA.
DR EMBL; U01742; AAD10552.1; -; Genomic_DNA.
DR EMBL; U02156; AAD12438.1; -; Genomic_DNA.
DR PIR; E64215; E64215.
DR RefSeq; WP_010869351.1; NC_000908.2.
DR AlphaFoldDB; P47386; -.
DR STRING; 243273.MG_140; -.
DR EnsemblBacteria; AAC71358; AAC71358; MG_140.
DR KEGG; mge:MG_140; -.
DR eggNOG; COG1112; Bacteria.
DR HOGENOM; CLU_000788_4_0_14; -.
DR OMA; WRERNND; -.
DR OrthoDB; 616258at2; -.
DR BioCyc; MGEN243273:G1GJ2-162-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR025103; DUF4011.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10887; PTHR10887; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF13195; DUF4011; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT CHAIN 1..1113
FT /note="Uncharacterized ATP-dependent helicase MG140"
FT /id="PRO_0000080728"
FT BINDING 313..320
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 267
FT /note="D -> R (in Ref. 2 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 394
FT /note="L -> W (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 1092..1100
FT /note="PIGVISKIR -> QLGWFLKSD (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1113 AA; 130580 MW; FF0C51F926725D3F CRC64;
MNDWQWLKNR LVNSKTKSVS FWLPQTSSNI IDIAELIKCC SELKNTSING LIDFLNQQDK
LEFNLTRLKE IDVEDGKQLF GIETSVYKHF QNEIARFYKQ VNKHFRETGS ESLFLALPVI
EGINEFNDIF RAPLLYVGVK LKVSPRFERF WLEINKEEIF LNPTIIGVET NKRNSLFKNN
YDTTKIDVND ALKVFSELEY EFRMPLTSEL KSFSKKAKSD FNTEKRTNYL INNVLLGIFD
VKGDQLFQNF NEILNTDPDV LDELLKDRRD LLLENREFRE QFDLKDTYLF SHLDIYQQYA
VKQALLGDLI IEGPPGTGKS ETIVNILVNL VLNNKKVLFV SEKVTALDVV YNRLGSFKHI
ALFNASVAAE KKRFYNQFAE FETYFTTYFS KKDLDATLPT FEGKWVDDIL GAFQALQALY
DTKINSGENL FSFKEIVSSF QMLDASYIKI KEYERFDEWV RVFSNPLWLE KHLSYQELKK
ELSQRWNGID NFYQLQSLLN QTKKRKVLNY VLEHFEQFNT VISPKHVLFY KPSNKSQLLL
KQLKQDVEQY TSLQRFQSPT KFETIKLNFI NQVNENPTPW FFSWFIQFHA KPLLEKLVSF
ESNIIKTKQA YLNGIESYVA SCKKLLKTTI LNNFFQLYQT NKDELLEICR QAKNPVLKEI
TWWFKKHFEL LKKLFPVHIM TLESAATLTP NQRGLYDYVV IDEASQVFLE RAIPILFRAD
KYIIAGDTKQ LKPANFFQSR AEYDVDEEFE DGNIEAAVHS SSLLHFLKNR SRILTLLKFH
YRSDSADLIA FTNNRIYDNE LIFMNKANAD QRVFIVHDVI DGIWKNNRNL QEARDVVQRL
EQLTTTNDYK KSLGVICFNK NQADLIEYLI DKQNNPLLNE WRERQNDVGE YEGLFVKNIE
NVQGDERDII IFSLGYDRSV NSYGPISKQG GENRLNVAIT RAKQRIELFK TNRGEDYNGL
SSSSLGSKLL VEYLLYCEAM AKNQGEKITF QAVKRKETKA KYELAVENDF FNQLQAIFGG
EFEIKRNVNE GAYFFSFVFY FNNIPYLAID FNIPIPTSRK QVMEGILYRE QFLKKRQWNL
INIWIDEWKL NPIGVISKIR SSLAVHQNQH EEI
