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Y1411_DROME
ID   Y1411_DROME             Reviewed;         710 AA.
AC   Q6NLL1; Q6NMV3; Q960Z3;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=WD repeat-containing protein CG11141;
GN   ORFNames=CG11141;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head, and Testis;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 222-710.
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=17372656; DOI=10.1039/b617545g;
RA   Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA   Eng J.K., Aebersold R., Tao W.A.;
RT   "An integrated chemical, mass spectrometric and computational strategy for
RT   (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT   Kc167 cells.";
RL   Mol. Biosyst. 3:275-286(2007).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-488, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
CC   -!- SIMILARITY: Belongs to the WD repeat KIAA0329 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK93183.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE013599; AAF59251.1; -; Genomic_DNA.
DR   EMBL; BT011551; AAS15687.1; -; mRNA.
DR   EMBL; BT012320; AAS77445.1; -; mRNA.
DR   EMBL; AY051759; AAK93183.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001286159.1; NM_001299230.1.
DR   RefSeq; NP_610282.1; NM_136438.4.
DR   RefSeq; NP_724559.1; NM_165525.3.
DR   AlphaFoldDB; Q6NLL1; -.
DR   IntAct; Q6NLL1; 1.
DR   STRING; 7227.FBpp0088070; -.
DR   iPTMnet; Q6NLL1; -.
DR   PaxDb; Q6NLL1; -.
DR   PRIDE; Q6NLL1; -.
DR   DNASU; 35672; -.
DR   EnsemblMetazoa; FBtr0088998; FBpp0088070; FBgn0033177.
DR   EnsemblMetazoa; FBtr0088999; FBpp0088071; FBgn0033177.
DR   EnsemblMetazoa; FBtr0345799; FBpp0311785; FBgn0033177.
DR   GeneID; 35672; -.
DR   KEGG; dme:Dmel_CG11141; -.
DR   UCSC; CG11141-RA; d. melanogaster.
DR   UCSC; CG11141-RB; d. melanogaster.
DR   FlyBase; FBgn0033177; CG11141.
DR   VEuPathDB; VectorBase:FBgn0033177; -.
DR   eggNOG; KOG3621; Eukaryota.
DR   GeneTree; ENSGT00940000157283; -.
DR   HOGENOM; CLU_026810_0_0_1; -.
DR   InParanoid; Q6NLL1; -.
DR   OMA; TEFDYQA; -.
DR   OrthoDB; 416267at2759; -.
DR   PhylomeDB; Q6NLL1; -.
DR   BioGRID-ORCS; 35672; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 35672; -.
DR   PRO; PR:Q6NLL1; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0033177; Expressed in testis and 23 other tissues.
DR   ExpressionAtlas; Q6NLL1; baseline and differential.
DR   Genevisible; Q6NLL1; DM.
DR   GO; GO:0005737; C:cytoplasm; IEA:GOC.
DR   GO; GO:0032527; P:protein exit from endoplasmic reticulum; ISS:FlyBase.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR029772; TECPR2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR23287:SF16; PTHR23287:SF16; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..710
FT                   /note="WD repeat-containing protein CG11141"
FT                   /id="PRO_0000351218"
FT   REPEAT          31..70
FT                   /note="WD 1"
FT   REPEAT          133..172
FT                   /note="WD 2"
FT   REGION          283..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          612..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          685..710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..307
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        693..710
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         488
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   MOD_RES         553
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:17372656"
SQ   SEQUENCE   710 AA;  79070 MW;  2B5A7CCECF8E4C71 CRC64;
     MASSKELCSI REWAPLTEVI ERIPARLQRG FFPANLNLTC VDATEEFLAM GSDAGIVFWY
     NRHTGEMQKL KAEVATRITC VRVVNSVEYM VAAGCANGQV SIFQIQKELP RDLDLVAPCT
     KSRPIERYTI RDLHKCVVSC CEWSKNGMKL YSGDRQGVVV LTELDYQAHL SKSVEILSEA
     YEIVQLSVRQ SYLLVATLYR CIVCQMDAQT SQWNITQVGK KDRKQLIDCG AIFLKKQEAN
     KPQLVCGRPG LRFWVADAAG NVSKTVIFRD AVLRSPTWEI PILNPKQRSE PSGTHHTSAS
     TSSTRHSGLA DGDVGYVASS NFRQLYLYDG HDSLLVTHDD ATLYVLNLDR LKVEAVARGL
     RKILDFCVCG KEIFVLEGNR TLLRLAPLPE PPNKTAKVIF NPLMPPPVPV LGSHLSQLES
     PIELQAEPVL QNAEECFELS PVEQLNLNVP IEIAVESPLT QQNRRLEIFR RIGEMDFEQS
     IVHTTRKTSV GKPPEASGVG IVEIGHETHE LRLPLTNAAT LMEASYCQME NNGLASPLDM
     KAAFLQHLPD ALSPTTLQKT VAEKAKTLAA ELDLPEVHLA PLSQEELHAV QAQTPQISDP
     LIRCYPTHLE EASIQTSSRE NATNPADDYH VGEPVDGIRS FGVSKRKMAP LKFVLSQPKP
     TLKLEENRDD EEYTSFLPDF RRAGDPLAIH KETPATSDSN TSSEWEFLDN
 
 
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