CAPSD_CNV
ID CAPSD_CNV Reviewed; 380 AA.
AC P15183;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Capsid protein;
DE AltName: Full=Coat protein;
DE AltName: Full=p41;
GN ORFNames=ORF2;
OS Cucumber necrosis virus (CNV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC Tolivirales; Tombusviridae; Procedovirinae; Tombusvirus.
OX NCBI_TaxID=12143;
OH NCBI_TaxID=3659; Cucumis sativus (Cucumber).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2705296; DOI=10.1016/0042-6822(89)90150-5;
RA Rochon D.M., Tremaine J.H.;
RT "Complete nucleotide sequence of the cucumber necrosis virus genome.";
RL Virology 169:251-259(1989).
RN [2]
RP RNA-BINDING, AND FUNCTION.
RX PubMed=20483445; DOI=10.1016/j.virol.2010.03.045;
RA Reade R., Kakani K., Rochon D.;
RT "A highly basic KGKKGK sequence in the RNA-binding domain of the Cucumber
RT necrosis virus coat protein is associated with encapsidation of full-length
RT CNV RNA during infection.";
RL Virology 403:181-188(2010).
CC -!- FUNCTION: Capsid protein self-assembles to form an icosahedral capsid
CC with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180
CC capsid proteins. {ECO:0000269|PubMed:20483445}.
CC -!- SUBUNIT: Homomultimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the icosahedral plant coat protein family.
CC {ECO:0000305}.
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DR EMBL; M25270; AAA42904.1; -; Genomic_RNA.
DR PIR; JA0131; VCVGCN.
DR RefSeq; NP_040955.1; NC_001469.1.
DR PDB; 4LLF; X-ray; 2.89 A; A/B/D/E/F/G/H/I/J/K/L/M/N/O/P=1-380.
DR PDBsum; 4LLF; -.
DR SMR; P15183; -.
DR GeneID; 1493950; -.
DR KEGG; vg:1493950; -.
DR Proteomes; UP000008565; Genome.
DR GO; GO:0039617; C:T=3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 2.60.120.20; -; 1.
DR InterPro; IPR000937; Capsid_prot_S-dom_vir.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF00729; Viral_coat; 1.
DR PRINTS; PR00233; ICOSAHEDRAL.
DR PROSITE; PS00555; ICOSAH_VIR_COAT_S; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Capsid protein; RNA-binding; T=3 icosahedral capsid protein;
KW Virion.
FT CHAIN 1..380
FT /note="Capsid protein"
FT /id="PRO_0000222861"
FT REGION 1..92
FT /note="R domain, interaction with RNA"
FT REGION 48..53
FT /note="Involved in encapsidation"
FT /evidence="ECO:0000305"
FT REGION 93..254
FT /note="S domain, virion shell"
FT REGION 255..380
FT /note="P domain, projecting"
FT STRAND 86..89
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 94..107
FT /evidence="ECO:0007829|PDB:4LLF"
FT HELIX 115..117
FT /evidence="ECO:0007829|PDB:4LLF"
FT TURN 131..133
FT /evidence="ECO:0007829|PDB:4LLF"
FT TURN 135..137
FT /evidence="ECO:0007829|PDB:4LLF"
FT HELIX 138..141
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 144..158
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 167..175
FT /evidence="ECO:0007829|PDB:4LLF"
FT TURN 184..186
FT /evidence="ECO:0007829|PDB:4LLF"
FT HELIX 187..189
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 191..196
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 202..205
FT /evidence="ECO:0007829|PDB:4LLF"
FT TURN 218..220
FT /evidence="ECO:0007829|PDB:4LLF"
FT HELIX 223..226
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 230..237
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 241..257
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 264..269
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 271..274
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 276..280
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 284..289
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 294..298
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 302..310
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 319..324
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 327..334
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 339..347
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 352..355
FT /evidence="ECO:0007829|PDB:4LLF"
FT STRAND 364..370
FT /evidence="ECO:0007829|PDB:4LLF"
SQ SEQUENCE 380 AA; 40878 MW; 793CB6B05CEC6669 CRC64;
MALVSRNNNM RTLAKLAAPL ATAGTRTIVD NKEAIWNGVK WIWGKLPKGK KGKNGNGALI
AHPQAFPGAI AAPISYAYAV KGRKPRFQTA KGSVRITHRE YVSVLSGTNG EFLRNNGTGP
NNDFSINPLN PFLFPWLVNI AANFDQYKFN SLRFEYVPLV NTTTNGRVAL YFDKDSEDPG
PDDRAALANY AHLSEISPWA ITKLTVPTDN VKRFISDTSS GDPKLINLGQ FGWVAYSGPT
AELGDIFVEY TVDLFEAQPT SPLLESLFRE SASSVQTRMG LPYFSLEVAS ATDLVWQARV
PGTYVVTIIF NSTVGGLTPS ISGGGTINSS FSVSTAGSSA YVANITIRVN ANLSLSGLTG
ATNAQLFAVR AITENAVQVV