Y1421_ARATH
ID Y1421_ARATH Reviewed; 587 AA.
AC Q9SH71;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Putative inactive receptor-like protein kinase At1g64210;
DE Flags: Precursor;
GN OrderedLocusNames=At1g64210; ORFNames=F22C12.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- INTERACTION:
CC Q9SH71; Q9M9S4: At1g14390; NbExp=2; IntAct=EBI-20651385, EBI-16954682;
CC Q9SH71; Q9SH71: At1g64210; NbExp=2; IntAct=EBI-20651385, EBI-20651385;
CC Q9SH71; C0LGJ9: At2g02780; NbExp=2; IntAct=EBI-20651385, EBI-20651541;
CC Q9SH71; C0LGK9: At2g24230; NbExp=2; IntAct=EBI-20651385, EBI-16965118;
CC Q9SH71; C0LGR6: At4g29180; NbExp=2; IntAct=EBI-20651385, EBI-20654480;
CC Q9SH71; C0LGT1: At5g10290; NbExp=2; IntAct=EBI-20651385, EBI-16954266;
CC Q9SH71; Q9LT96: At5g49770; NbExp=2; IntAct=EBI-20651385, EBI-17123993;
CC Q9SH71; Q9SYQ8: CLV1; NbExp=2; IntAct=EBI-20651385, EBI-1646111;
CC Q9SH71; Q9LYN8: EMS1; NbExp=2; IntAct=EBI-20651385, EBI-1640748;
CC Q9SH71; Q9SN97: F18L15.140; NbExp=2; IntAct=EBI-20651385, EBI-20655031;
CC Q9SH71; Q8GX94: LRR-RLK; NbExp=2; IntAct=EBI-20651385, EBI-16955556;
CC Q9SH71; Q8GY50: LRR-RLK; NbExp=2; IntAct=EBI-20651385, EBI-20658163;
CC Q9SH71; Q9M0D8: LRR-RLK; NbExp=2; IntAct=EBI-20651385, EBI-16955231;
CC Q9SH71; Q93ZS4: NIK3; NbExp=2; IntAct=EBI-20651385, EBI-17121474;
CC Q9SH71; Q9ZVR7: PSKR1; NbExp=2; IntAct=EBI-20651385, EBI-16172949;
CC Q9SH71; Q9FN37: PSKR2; NbExp=2; IntAct=EBI-20651385, EBI-16902047;
CC Q9SH71; Q9FRS6: PXL1; NbExp=2; IntAct=EBI-20651385, EBI-16946268;
CC Q9SH71; Q9SKB2: SOBIR1; NbExp=2; IntAct=EBI-20651385, EBI-16905883;
CC Q9SH71; Q9SIT1: TMK3; NbExp=2; IntAct=EBI-20651385, EBI-16896864;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
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DR EMBL; AC007764; AAF24582.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34210.1; -; Genomic_DNA.
DR RefSeq; NP_176603.1; NM_105095.2.
DR AlphaFoldDB; Q9SH71; -.
DR SMR; Q9SH71; -.
DR BioGRID; 27947; 62.
DR IntAct; Q9SH71; 79.
DR STRING; 3702.AT1G64210.1; -.
DR PaxDb; Q9SH71; -.
DR PRIDE; Q9SH71; -.
DR EnsemblPlants; AT1G64210.1; AT1G64210.1; AT1G64210.
DR GeneID; 842726; -.
DR Gramene; AT1G64210.1; AT1G64210.1; AT1G64210.
DR KEGG; ath:AT1G64210; -.
DR Araport; AT1G64210; -.
DR TAIR; locus:2024517; AT1G64210.
DR eggNOG; ENOG502QTFK; Eukaryota.
DR HOGENOM; CLU_000288_92_6_1; -.
DR InParanoid; Q9SH71; -.
DR OMA; CYGCIGD; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q9SH71; -.
DR PRO; PR:Q9SH71; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SH71; baseline and differential.
DR Genevisible; Q9SH71; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..587
FT /note="Putative inactive receptor-like protein kinase
FT At1g64210"
FT /id="PRO_0000401351"
FT TOPO_DOM 20..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..587
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 89..112
FT /note="LRR 1"
FT REPEAT 113..136
FT /note="LRR 2"
FT REPEAT 137..160
FT /note="LRR 3"
FT REPEAT 161..183
FT /note="LRR 4"
FT REPEAT 184..205
FT /note="LRR 5"
FT DOMAIN 307..581
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 313..321
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 335
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 309
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 462
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 463
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 466
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 477
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 587 AA; 65331 MW; A220304E519D6F46 CRC64;
MQIFLFFFSL ILCFVLISSQ TLEDDKKALL HFLSSFNSSR LHWNQSSDVC HSWTGVTCNE
NGDRIVSVRL PAVGFNGLIP PFTISRLSSL KFLSLRKNHF TGDFPSDFTN LKSLTHLYLQ
HNHLSGPLLA IFSELKNLKV LDLSNNGFNG SIPTSLSGLT SLQVLNLANN SFSGEIPNLH
LPKLSQINLS NNKLIGTIPK SLQRFQSSAF SGNNLTERKK QRKTPFGLSQ LAFLLILSAA
CVLCVSGLSF IMITCFGKTR ISGKLRKRDS SSPPGNWTSR DDNTEEGGKI IFFGGRNHLF
DLDDLLSSSA EVLGKGAFGT TYKVTMEDMS TVVVKRLKEV VVGRREFEQQ MEIIGMIRHE
NVAELKAYYY SKDDKLAVYS YYNHGSLFEI LHGNRGRYHR VPLDWDARLR IATGAARGLA
KIHEGKFIHG NIKSSNIFLD SQCYGCIGDV GLTTIMRSLP QTTCLTSGYH APEITDTRRS
TQFSDVYSFG VVLLELLTGK SPVSQAELVP TGGENMDLAS WIRSVVAKEW TGEVFDMEIL
SQSGGFEEEM VEMLQIGLAC VALKQQERPH IAQVLKLIED IRSVDAE
