ID   Y1421_MYCTU             Reviewed;         301 AA.
AC   P9WFQ3; L0T878; P67106; P71690;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Nucleotide-binding protein Rv1421 {ECO:0000255|HAMAP-Rule:MF_00636};
GN   OrderedLocusNames=Rv1421; ORFNames=MTCY21B4.39;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Displays ATPase and GTPase activities. {ECO:0000255|HAMAP-
CC       Rule:MF_00636}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the RapZ-like family. {ECO:0000255|HAMAP-
CC       Rule:MF_00636}.
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DR   EMBL; AL123456; CCP44180.1; -; Genomic_DNA.
DR   PIR; B70903; B70903.
DR   RefSeq; NP_215937.1; NC_000962.3.
DR   RefSeq; WP_003898873.1; NZ_NVQJ01000038.1.
DR   AlphaFoldDB; P9WFQ3; -.
DR   SMR; P9WFQ3; -.
DR   STRING; 83332.Rv1421; -.
DR   PaxDb; P9WFQ3; -.
DR   DNASU; 886676; -.
DR   GeneID; 45425399; -.
DR   GeneID; 886676; -.
DR   KEGG; mtu:Rv1421; -.
DR   TubercuList; Rv1421; -.
DR   eggNOG; COG1660; Bacteria.
DR   OMA; TVMSFGF; -.
DR   PhylomeDB; P9WFQ3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00636; RapZ_like; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005337; RapZ-like.
DR   PANTHER; PTHR30448; PTHR30448; 1.
DR   Pfam; PF03668; ATP_bind_2; 1.
DR   PIRSF; PIRSF005052; P-loopkin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..301
FT                   /note="Nucleotide-binding protein Rv1421"
FT                   /id="PRO_0000107732"
FT   BINDING         24..31
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00636"
FT   BINDING         75..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00636"
SQ   SEQUENCE   301 AA;  32912 MW;  FB546C303B51C01A CRC64;
     MMNHARGVEN RSEGGGIDVV LVTGLSGAGR GTAAKVLEDL GWYVADNLPP QLITRMVDFG
     LAAGSRITQL AVVMDVRSRG FTGDLDSVRN ELATRAITPR VVFMEASDDT LVRRYEQNRR
     SHPLQGEQTL AEGIAAERRM LAPVRATADL IIDTSTLSVG GLRDSIERAF GGDGGATTSV
     TVESFGFKYG LPMDADMVMD VRFLPNPHWV DELRPLTGQH PAVRDYVLHR PGAAEFLESY
     HRLLSLVVDG YRREGKRYMT IAIGCTGGKH RSVAIAEALM GLLRSDQQLS VRALHRDLGR
     E