ID   Y1429_THEAC             Reviewed;         499 AA.
AC   Q9HIB2;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=UPF0159 protein Ta1429;
GN   OrderedLocusNames=Ta1429;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- SIMILARITY: Belongs to the UPF0159 family. {ECO:0000305}.
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DR   EMBL; AL445067; CAC12549.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HIB2; -.
DR   STRING; 273075.Ta1429m; -.
DR   PRIDE; Q9HIB2; -.
DR   DNASU; 1457112; -.
DR   EnsemblBacteria; CAC12549; CAC12549; CAC12549.
DR   KEGG; tac:Ta1429; -.
DR   eggNOG; arCOG01884; Archaea.
DR   HOGENOM; CLU_024745_0_0_2; -.
DR   OMA; MHRHRRC; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0050797; F:thymidylate synthase (FAD) activity; IEA:InterPro.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1360.170; -; 2.
DR   InterPro; IPR003669; Thymidylate_synthase_ThyX.
DR   InterPro; IPR036098; Thymidylate_synthase_ThyX_sf.
DR   PANTHER; PTHR34934; PTHR34934; 2.
DR   Pfam; PF02511; Thy1; 2.
DR   SUPFAM; SSF69796; SSF69796; 2.
DR   PROSITE; PS51331; THYX; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat.
FT   CHAIN           1..499
FT                   /note="UPF0159 protein Ta1429"
FT                   /id="PRO_0000220645"
FT   DOMAIN          1..246
FT                   /note="ThyX 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00661"
FT   DOMAIN          271..476
FT                   /note="ThyX 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00661"
SQ   SEQUENCE   499 AA;  57623 MW;  C457FDD902317B43 CRC64;
     MIDRGALMSR YSRASDPDIR SVFHREFEGN QKRSEDFYRR IFLEYGDESI AELVTAQVGI
     QNVSNVISKV IEEIRIGLSY LEKSTRYVAY DRKVDGHYLF MQAEKIGLSG EAAREYTDLC
     NRLFDLYSST LPRIEEEISR QWPIESFDFN IDGNPRNYKE LDENGRKLAQ KSYRSSVRSR
     ALDDARFILP ASTLTNMGVS GNGRSFIHLI QKLMEYGVPE SERLAHDLYE ELKGEFPQII
     DDALSQHGQD IINYKRSLAS LFPYTDGGRF EKVRLIKYSN EREEMQKVLA LLMYPFAEDA
     SGIISRIKAM ELSEASAILE RIRDLRKNRR MKVGRPFEAV NYVFEVTTNY GAFRDLQRHR
     FLSIVRKPLT VSYGFDVPPI IAKMPDLSEE YAEAMKDAER VYRIIKERYG AWIAQYAVPF
     AYRYPVVFTT NLAEATYFIE LRSTPQAHFD LRDIAIRMYN EIKSVHPSLA GIIKFVDTGD
     YPLGRLSAEV RKNVKAGGI