ID   Y1430_HAEIN             Reviewed;         252 AA.
AC   P45200;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable NADP-dependent dehydrogenase HI_1430;
DE            EC=1.1.1.-;
GN   OrderedLocusNames=HI_1430;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; L42023; AAC23077.1; -; Genomic_DNA.
DR   PIR; H64122; H64122.
DR   RefSeq; NP_439579.1; NC_000907.1.
DR   RefSeq; WP_005693935.1; NC_000907.1.
DR   AlphaFoldDB; P45200; -.
DR   SMR; P45200; -.
DR   STRING; 71421.HI_1430; -.
DR   EnsemblBacteria; AAC23077; AAC23077; HI_1430.
DR   KEGG; hin:HI_1430; -.
DR   PATRIC; fig|71421.8.peg.1487; -.
DR   eggNOG; COG4221; Bacteria.
DR   HOGENOM; CLU_010194_2_10_6; -.
DR   OMA; WRWMWET; -.
DR   PhylomeDB; P45200; -.
DR   BioCyc; HINF71421:G1GJ1-1453-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030497; P:fatty acid elongation; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..252
FT                   /note="Probable NADP-dependent dehydrogenase HI_1430"
FT                   /id="PRO_0000054831"
FT   ACT_SITE        150
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         7..31
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         137
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   252 AA;  27398 MW;  227FB2E8CE7D9A98 CRC64;
     MKTTTALVTG ATAGFGLAIC KKLIEAGYKV IGTGRRADRL AEIHSQLGNN FLPLAFDIRD
     EQATINALNT LPEGWQAVDL LVNNAGLALG LEPAHKADLQ DWYQMIDTNI KGLVTITRLV
     LPNMVARNYG QIINLSSIAG TYPYAGSNVY GGTKAFVTQF SLNLRADLAG TKIRVSNVEP
     GLCGGTEFSN VRFHGDDERA AKVYENVQSV QPEDIANIVL WLHQQPEHVN INRIEVMPTA
     QSFAGMSVSK EK