ID   Y1436_DICDI             Reviewed;         200 AA.
AC   Q556P3; Q86JY5;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Glutathione S-transferase domain-containing protein DDB_G0273153/DDB_G0273923;
GN   ORFNames=DDB_G0273153;
GN   and
GN   ORFNames=DDB_G0273923;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70652.2; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70794.2; -; Genomic_DNA.
DR   RefSeq; XP_644578.3; XM_639486.2.
DR   RefSeq; XP_644673.4; XM_639581.2.
DR   AlphaFoldDB; Q556P3; -.
DR   SMR; Q556P3; -.
DR   STRING; 44689.DDB0305017; -.
DR   PaxDb; Q556P3; -.
DR   GeneID; 8618767; -.
DR   GeneID; 8619209; -.
DR   KEGG; ddi:DDB_G0273153; -.
DR   KEGG; ddi:DDB_G0273923; -.
DR   dictyBase; DDB_G0273153; -.
DR   dictyBase; DDB_G0273923; -.
DR   eggNOG; KOG1695; Eukaryota.
DR   HOGENOM; CLU_039475_1_0_1; -.
DR   InParanoid; Q556P3; -.
DR   OMA; IKHEINQ; -.
DR   PhylomeDB; Q556P3; -.
DR   Reactome; R-DDI-156590; Glutathione conjugation.
DR   Reactome; R-DDI-189483; Heme degradation.
DR   Reactome; R-DDI-3299685; Detoxification of Reactive Oxygen Species.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-9748787; Azathioprine ADME.
DR   Reactome; R-DDI-9753281; Paracetamol ADME.
DR   PRO; PR:Q556P3; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR   GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   Pfam; PF14497; GST_C_3; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..200
FT                   /note="Glutathione S-transferase domain-containing protein
FT                   DDB_G0273153/DDB_G0273923"
FT                   /id="PRO_0000350743"
FT   DOMAIN          1..71
FT                   /note="GST N-terminal"
FT   DOMAIN          73..195
FT                   /note="GST C-terminal"
SQ   SEQUENCE   200 AA;  23232 MW;  7DE05441AE1AB373 CRC64;
     MISSIYIFKI LLSYLGVEYE INQLSEINQE FTNKLESYNQ FIKHTQKDED YLLGQSAVIS
     RYISNNHNFS GKSLQESARV DDIVESVLEI IEEYVLPIIN SNIINEEITK LLCTHFNDFE
     NQLSKSTFSA GDSTTLADLY LFILYDITLR YLENHGHLAH HFNEKYPHLE RLKLHFLSNK
     SVSEFINSNN INSQSSQLII