ID   Y1439_ARATH             Reviewed;        1002 AA.
AC   P93820; F4I487; Q0WQI5;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 3.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=BTB/POZ domain-containing protein At1g04390;
GN   OrderedLocusNames=At1g04390; ORFNames=F19P19.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   DOMAIN BTB.
RX   PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA   Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA   Vierstra R.D.;
RT   "Cullins 3a and 3b assemble with members of the broad
RT   complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT   ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL   J. Biol. Chem. 280:18810-18821(2005).
CC   -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P93820-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P93820-2; Sequence=VSP_041110;
CC   -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC       of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB70453.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC000104; AAB70453.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE27691.2; -; Genomic_DNA.
DR   EMBL; AK228712; BAF00614.1; -; mRNA.
DR   PIR; G86175; G86175.
DR   RefSeq; NP_001318918.1; NM_001331477.1. [P93820-1]
DR   AlphaFoldDB; P93820; -.
DR   BioGRID; 24765; 1.
DR   PaxDb; P93820; -.
DR   PRIDE; P93820; -.
DR   ProteomicsDB; 243031; -. [P93820-1]
DR   EnsemblPlants; AT1G04390.1; AT1G04390.1; AT1G04390. [P93820-1]
DR   GeneID; 839530; -.
DR   Gramene; AT1G04390.1; AT1G04390.1; AT1G04390. [P93820-1]
DR   KEGG; ath:AT1G04390; -.
DR   Araport; AT1G04390; -.
DR   TAIR; locus:2018264; AT1G04390.
DR   eggNOG; ENOG502QR8C; Eukaryota.
DR   InParanoid; P93820; -.
DR   OMA; RWNSDCP; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:P93820; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; P93820; baseline and differential.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.710.10; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR044953; At1g04390-like.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR35918; PTHR35918; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..1002
FT                   /note="BTB/POZ domain-containing protein At1g04390"
FT                   /id="PRO_0000408532"
FT   DOMAIN          680..758
FT                   /note="BTB 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          808..889
FT                   /note="BTB 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   VAR_SEQ         1..465
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_041110"
SQ   SEQUENCE   1002 AA;  112373 MW;  981A2D7A1CC5FF01 CRC64;
     MASSKGGNTT AHINTLHHRL YHALNLGFRV CDEKEKKWKC TDIEIQRHVV KSISAFLDCF
     SRATANNRLI KDSISDIAGA LVFILGSKNR AVVGLAANVV IRLIRIVPPS ILHSYSLDLV
     ESLSPLLCCQ QFDVSLPCAV ALNAILVNVR ETKEKEVWKI LEDEKTVVSV VGNLQIFSEG
     SMSVEWFQEM ALLLSTIMLK WPQSRYSVWN NPALMGVLES VSQKPDMGLT VATLKLYSSL
     ALCGHGANEL LDNGKPMLDM MISCMEESSS QNARIEGLKL AQRLATGNRE CLKMINMCSE
     SLVKATVRTM GKWFLSSGKL ELDQMSLLVE ACKLALITRW EGQHHIYFWK YRISEALLSL
     VVENFHSQSL DGYVSLEEEV LVAEKVLNAN FLPSLRSYVW DIIGFLAAHC EEEFDSILRG
     DELCLNFLVT CACLSFSRSV QKGYQICQND IISASHSESA SRAVLMMICS PSKYISSRAR
     VTLSFILEEG GEQNLNSLVN FLSYIPSSGG YILPNILQTT VCLVGFACYS SIPQYASFIL
     RKQGLEILLS FCSWYQRNWE NIGASSFAPS SQSITEKRIC CWVCTEDWDN KDAFLLYALL
     ALAELVNHSF FGQNHAEELS MKSGNLKDRL CTTLKEIRDG TYGSGPRWYA AHILSYFGYY
     GFEHKLGKRL MCAYEDEEYS DMRLLFASGN SASVNKVIIA VRCPMLLPPK EGAHSSSTIS
     TEKSQRTVQE IRMSANVDIL ALVKLLEFAY SGYVEVESTT LKKLKPLAKH CKAKVLLQML
     CRRRPKWGSS IPEIDIPLAL TPKLIHFSDV ILVPKETNVA CFNCRMCSLT SPHAHSHRVI
     LSSGCEYLRA LFRSGMQESH LDRLNVPVSW LGLTKLVSWF YSDELPKPPS GCKWNNMDTE
     AKLDELQAYV EIYSLSEWWI MEELQNDCAH VILSCLESAR ELSIKTIELA ASFSMWKLVE
     AAANHAAPIY HQLRDSGELD ELDDELVNLI RTAAVQFSQQ GG