ID   CAPSD_GOCV              Reviewed;         250 AA.
AC   Q91EK1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   23-FEB-2022, entry version 66.
DE   RecName: Full=Probable capsid protein;
GN   Name=Cap; ORFNames=ORFC1;
OS   Goose circovirus (GoCV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes;
OC   Cirlivirales; Circoviridae; Circovirus.
OX   NCBI_TaxID=146032;
OH   NCBI_TaxID=8842; Anser (geese).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11485403; DOI=10.1006/viro.2001.0985;
RA   Todd D., Weston J.H., Soike D., Smyth J.A.;
RT   "Genome sequence determinations and analyses of novel circoviruses from
RT   goose and pigeon.";
RL   Virology 286:354-362(2001).
CC   -!- FUNCTION: Self-assembles to form the virion icosahedral capsid with a
CC       T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows
CC       the virus to be very stable in the environment and resistant to some
CC       disinfectants, including detergents. Essential for the initial
CC       attachment to heparan sulfate moieties and chondroitin sulfate B of the
CC       host cell surface proteoglycans. After attachment, the virus is
CC       endocytosed and traffics to the nucleus. The capsid protein binds and
CC       transports the viral genome and Rep across the nuclear envelope (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Assembles in the nucleus, presumably in an
CC       immature form, then migrates to the cytoplasm once assembled as mature
CC       virion. Interacts with Rep; this interaction relocates Rep into the
CC       nucleus (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the circoviridae capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; AJ304456; CAC50263.1; -; Genomic_DNA.
DR   RefSeq; NP_150370.1; NC_003054.1.
DR   SMR; Q91EK1; -.
DR   GeneID; 1732844; -.
DR   KEGG; vg:1732844; -.
DR   Proteomes; UP000185275; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039615; C:T=1 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:InterPro.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.950; -; 1.
DR   InterPro; IPR003383; Circovirus_capsid.
DR   InterPro; IPR038652; Circovirus_capsid_sf.
DR   Pfam; PF02443; Circo_capsid; 1.
PE   3: Inferred from homology;
KW   Capsid protein; DNA-binding; Host nucleus; Host-virus interaction;
KW   T=1 icosahedral capsid protein; Viral attachment to host cell;
KW   Viral penetration into host cytoplasm; Viral penetration into host nucleus;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..250
FT                   /note="Probable capsid protein"
FT                   /id="PRO_0000319850"
FT   REGION          1..38
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5..38
FT                   /note="Nuclear localization signals"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        9..24
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   250 AA;  29046 MW;  5B788F4ED12A2F90 CRC64;
     MPLYRARPRS LYSRRRRATN RRRRYRRRRL HIGRIRSKYT IFNVKQTQNI SFTFFGTGSP
     DKNKWQAMSL EAVQSSGTSP KPGINLRFAV FGDRLPGTGN QYHYPFDYYM IRMVKVELRP
     AFNPFQRVRT QGSTYIDKEG NITTTTSGGE WNVDPYAAMS SRKTWSPHRY HKRVFVPKPT
     IQQGGTGTNI WSTWYTPGGR QLWLNSIQDN VVFYGMGMSL RQAEDTAAPL TVEATITYYI
     RFGQWTGLSP