Y1459_MYCTU
ID Y1459_MYCTU Reviewed; 591 AA.
AC O53150; L0T9P4;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Alpha-(1->6)-mannopyranosyltransferase Rv1459c;
DE EC=2.4.1.-;
GN OrderedLocusNames=Rv1459c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18452585; DOI=10.1111/j.1365-2958.2008.06265.x;
RA Mishra A.K., Alderwick L.J., Rittmann D., Wang C., Bhatt A.,
RA Jacobs W.R. Jr., Takayama K., Eggeling L., Besra G.S.;
RT "Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from
RT Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505,
RT affords a lipomannan- and lipoarabinomannan-deficient mutant.";
RL Mol. Microbiol. 68:1595-1613(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Catalyzes the addition of alpha-(1->6)-mannose residue.
CC {ECO:0000269|PubMed:18452585}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:18452585}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MptA/B family. {ECO:0000305}.
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DR EMBL; AL123456; CCP44218.1; -; Genomic_DNA.
DR PIR; F70871; F70871.
DR RefSeq; NP_215975.1; NC_000962.3.
DR AlphaFoldDB; O53150; -.
DR STRING; 83332.Rv1459c; -.
DR PaxDb; O53150; -.
DR DNASU; 886585; -.
DR GeneID; 886585; -.
DR KEGG; mtu:Rv1459c; -.
DR TubercuList; Rv1459c; -.
DR eggNOG; ENOG5032QSS; Bacteria.
DR OMA; MIVWALP; -.
DR PhylomeDB; O53150; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Glycosyltransferase; Membrane; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..591
FT /note="Alpha-(1->6)-mannopyranosyltransferase Rv1459c"
FT /id="PRO_0000420594"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 569..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 62693 MW; B78B1B819529C57C CRC64;
MAARHHTLSW SIASLHGDEQ AVGAPLTTTE LTALARTRLF GATGTVLMAI GALGAGARPV
VQDPTFGVRL LNLPSRIQTV SLTMTTTGAV MMALAWLMLG RFTLGRRRMS RGKLDRTLLL
WMLPLLIAPP MYSKDVYSYL AQSEIGRDGL DPYRVGPASG LGLGHVFTLS VPSLWRETPA
PYGPLFLWIG RGISSLTGEN IVAAVLCHRL VVLIGVTLIV WATPRLAQRC GVAEVSALWL
GAANPLLIMH LVAGIHNEAL MLGLMLTGVE FALRGLDMAN TPRPSPETWR LGPATIRASR
RPELGASPRA GASRAVKPRP EWGPLAMLLA GSILITLSSQ VKLPSLLAMG FVTTVLAYRW
GGNLRALLLA AAVMASLTLA IMAILGWASG LGFGWINTLG TANVVRSWMS PPTLLALGTG
HVGILLGLGD HTTAVLSLTR AIGVLIITVM VCWLLLAVLR GRLHPIGGLG VALAVTVLLF
PVVQPWYLLW AIIPLAAWAT RPGFRVAAIL ATLIVGIFGP TANGDRFALF QIVDATAASA
IIVILLIALT YTRLPWRPLA AEQVVTAAES ASKTPATRRP TAAPDAYADS T
