Y1459_PYRHO
ID Y1459_PYRHO Reviewed; 310 AA.
AC O59128;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Putative sugar kinase PH1459 {ECO:0000305};
DE EC=2.7.1.- {ECO:0000305};
GN OrderedLocusNames=PH1459; ORFNames=PHCC008;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 8-309 IN COMPLEXES WITH ATP AND
RP AN ATP ANALOG.
RG New York SGX Research Center for Structural Genomics (NYSGXRC);
RT "Crystal structure of an uncharacterized sugar kinase PH1459 from
RT Pyrococcus horikoshii in complexes with ATP and AMP-PNP.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC {ECO:0000305}.
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DR EMBL; BA000001; BAA30566.1; -; Genomic_DNA.
DR PIR; F71020; F71020.
DR PDB; 3EWM; X-ray; 1.90 A; A/B=8-309.
DR PDB; 3GBU; X-ray; 2.20 A; A/B/C/D=8-309.
DR PDB; 3IH0; X-ray; 1.90 A; A/B=8-309.
DR PDBsum; 3EWM; -.
DR PDBsum; 3GBU; -.
DR PDBsum; 3IH0; -.
DR AlphaFoldDB; O59128; -.
DR SMR; O59128; -.
DR STRING; 70601.3257883; -.
DR EnsemblBacteria; BAA30566; BAA30566; BAA30566.
DR KEGG; pho:PH1459; -.
DR eggNOG; arCOG00014; Archaea.
DR OMA; NWRPTFW; -.
DR EvolutionaryTrace; O59128; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR002139; Ribo/fructo_kinase.
DR InterPro; IPR029056; Ribokinase-like.
DR Pfam; PF00294; PfkB; 1.
DR PRINTS; PR00990; RIBOKINASE.
DR SUPFAM; SSF53613; SSF53613; 1.
DR PROSITE; PS00583; PFKB_KINASES_1; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Kinase; Nucleotide-binding; Transferase.
FT CHAIN 1..310
FT /note="Putative sugar kinase PH1459"
FT /id="PRO_0000080153"
FT BINDING 194
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0007744|PDB:3GBU"
FT BINDING 219
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0007744|PDB:3GBU"
FT BINDING 224
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0007744|PDB:3GBU"
FT STRAND 8..12
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 15..24
FT /evidence="ECO:0007829|PDB:3EWM"
FT TURN 26..28
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 31..37
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 39..49
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 53..63
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 64..75
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 83..89
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 92..97
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 99..102
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 104..107
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 112..114
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 118..120
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 123..128
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 130..136
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 137..140
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 144..155
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 159..164
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 169..172
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 176..189
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 191..196
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 197..204
FT /evidence="ECO:0007829|PDB:3EWM"
FT TURN 205..207
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 213..219
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 221..223
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 224..229
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 232..237
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 249..263
FT /evidence="ECO:0007829|PDB:3EWM"
FT STRAND 264..266
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 269..283
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 295..298
FT /evidence="ECO:0007829|PDB:3EWM"
FT HELIX 302..308
FT /evidence="ECO:0007829|PDB:3EWM"
SQ SEQUENCE 310 AA; 33987 MW; F8CC41B678BE8611 CRC64;
MNLVFGMIAS IGELLIDLIS VEEGDLKDVR LFEKHPGGAP ANVAVGVSRL GVKSSLISKV
GNDPFGEYLI EELSKENVDT RGIVKDEKKH TGIVFVQLKG ASPSFLLYDD VAYFNMTLND
INWDIVEEAK IVNFGSVILA RNPSRETVMK VIKKIKGSSL IAFDVNLRLD LWRGQEEEMI
KVLEESIKLA DIVKASEEEV LYLENQGVEV KGSMLTAITL GPKGCRLIKN ETVVDVPSYN
VNPLDTTGAG DAFMAALLVG ILKLKGLDLL KLGKFANLVA ALSTQKRGAW STPRKDELLK
YKEAREVLAP
