ID   Y1462_MYCTU             Reviewed;         397 AA.
AC   P9WFP5; L0T6Q6; O53153;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=UPF0051 protein Rv1462;
GN   OrderedLocusNames=Rv1462; ORFNames=MTV007.09;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the UPF0051 (ycf24) family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44221.1; -; Genomic_DNA.
DR   PIR; A70872; A70872.
DR   RefSeq; NP_215978.1; NC_000962.3.
DR   RefSeq; WP_003916827.1; NZ_NVQJ01000004.1.
DR   AlphaFoldDB; P9WFP5; -.
DR   SMR; P9WFP5; -.
DR   STRING; 83332.Rv1462; -.
DR   iPTMnet; P9WFP5; -.
DR   PaxDb; P9WFP5; -.
DR   PRIDE; P9WFP5; -.
DR   DNASU; 886567; -.
DR   GeneID; 886567; -.
DR   KEGG; mtu:Rv1462; -.
DR   TubercuList; Rv1462; -.
DR   eggNOG; COG0719; Bacteria.
DR   OMA; HAVWIGD; -.
DR   PhylomeDB; P9WFP5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   GO; GO:0052572; P:response to host immune response; IEP:MTBBASE.
DR   InterPro; IPR000825; SUF_FeS_clus_asmbl_SufBD.
DR   InterPro; IPR037284; SUF_FeS_clus_asmbl_SufBD_sf.
DR   InterPro; IPR011542; SUF_FeS_clus_asmbl_SufD.
DR   PANTHER; PTHR43575; PTHR43575; 1.
DR   Pfam; PF01458; SUFBD; 1.
DR   SUPFAM; SSF101960; SSF101960; 1.
DR   TIGRFAMs; TIGR01981; sufD; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:21969609"
FT   CHAIN           2..397
FT                   /note="UPF0051 protein Rv1462"
FT                   /id="PRO_0000147386"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0007744|PubMed:21969609"
SQ   SEQUENCE   397 AA;  42523 MW;  6AFD58D1796B9612 CRC64;
     MTAPGLTAAV EGIAHNKGEL FASFDVDAFE VPHGRDEIWR FTPLRRLRGL HDGSARATGS
     ATITVSERPG VYTQTVRRGD PRLGEGGVPT DRVAAQAFSS FNSATLVTVE RDTQVVEPVG
     ITVTGPGEGA VAYGHLQVRI EELGEAVVVI DHRGGGTYAD NVEFVVDDAA RLTAVWIADW
     ADNTVHLSAH HARIGKDAVL RHVTVMLGGD VVRMSAGVRF CGAGGDAELL GLYFADDGQH
     LESRLLVDHA HPDCKSNVLY KGALQGDPAS SLPDAHTVWV GDVLIRAQAT GTDTFEVNRN
     LVLTDGARAD SVPNLEIETG EIVGAGHASA TGRFDDEQLF YLRSRGIPEA QARRLVVRGF
     FGEIIAKIAV PEVRERLTAA IEHELEITES TEKTTVS