Y146_MYCGE
ID Y146_MYCGE Reviewed; 424 AA.
AC Q49399;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=UPF0053 protein MG146;
DE AltName: Full=VXpSPT7_orf424;
GN OrderedLocusNames=MG146;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR EMBL; L43967; AAC71364.1; -; Genomic_DNA.
DR PIR; B64216; B64216.
DR RefSeq; WP_010869353.1; NC_000908.2.
DR AlphaFoldDB; Q49399; -.
DR SMR; Q49399; -.
DR STRING; 243273.MG_146; -.
DR EnsemblBacteria; AAC71364; AAC71364; MG_146.
DR KEGG; mge:MG_146; -.
DR eggNOG; COG1253; Bacteria.
DR HOGENOM; CLU_015237_4_1_14; -.
DR OMA; DLMIPRV; -.
DR OrthoDB; 1155802at2; -.
DR BioCyc; MGEN243273:G1GJ2-169-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; DUF21; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; SSF54631; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain; Cell membrane; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..424
FT /note="UPF0053 protein MG146"
FT /id="PRO_0000088378"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 6..191
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT DOMAIN 210..270
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 272..332
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ SEQUENCE 424 AA; 48720 MW; A361AAE5B995DA87 CRC64;
MDSAPSGLTL TVIILSIILL AFISTVVSAY ETAITSLTPY RWKNYIKTNN KQDKLSTKII
NHFQNHYSSC LITILITNNI VAIMVSNILF LALEQTIKNE LLSSVLNLVV SGVLIVSFCE
ILPKTLGRIN VIRTLVLFAY LVYFFYLIFW PITKLTSLIL KKYENPLPVS RKDVYYFIDE
IEQNGLFSKE DSLLIKKTLI FDQVLVKKVM IKWKKVAYCY LNDSINLIAK QFLQRQFSRM
PVVDKTTNKI VGFIHLKDFF TAKEANPKSL DLNQLLYPVV LVQDSTPIKQ ALRQMRLNRA
HLAVVNDKHE KTIGIVSMED IIEELVGEIY DEHDDIQPIQ VLDENVWLVL PNVKAAYFFN
KWIKPDLVKS KNITIQHYLA SLDNDSFACQ NKLDTPLFSV EVIADSEDKT KILYEIRKKS
DVIA
